Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F9 | P00740 | 1/20 | 0.48 |
| ▸ | F10 | P00742 | 1/20 | 0.48 |
| ▸ | EDNRA | P25101 | 2/20 | 0.47 |
| ▸ | MMP13 | P45452 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | GPR132 | Q9UNW8 | 7/20 | 0.41 |
| ▸ | CMKLR2 | P46091 | 1/20 | 0.41 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.41 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.41 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.41 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.41 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.41 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8024562 | 0.89 | MMP13 (0.46) | F9F10MMP13MEN1KMT2A | |
| SCHEMBL8020338 | 0.83 | F9 (0.41) | F9F10EDNRAMMP13GPR132 | |
| SCHEMBL7244247 | 0.79 | F9 (0.46) | F9F10EDNRAMAPK1GPR132 | |
| SCHEMBL8023446 | 0.78 | NMT1 (0.48) | EDNRAMEN1KMT2A | |
| SCHEMBL8027254 | 0.78 | MMP13 (0.44) | F9F10MMP13MEN1KMT2A | |
| SCHEMBL8024355 | 0.77 | F9 (0.44) | F9F10MMP13MAPK1MEN1 | |
| SCHEMBL10953368 | 0.75 | F9 (0.51) | F9F10GPR132 | |
| SCHEMBL8021028 | 0.75 | F9 (0.43) | F9F10EDNRAGPR132CMKLR2 | |
| SCHEMBL8024350 | 0.74 | HPGD (0.55) | F9F10MAPK1GPR132KMT2A | |
| SCHEMBL8024530 | 0.74 | F9 (0.48) | F9F10MMP13GPR132MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6040309-A | ACTIVE MATERIAL TREATING OF RESTENOSIS, RENAL FAILURE, PULMONARY HYPERTENSION, BENIGN PROSTATIC HYPERTROPHY, MALE ERECTILE DYSFUNCTION, CONGESTIVE HEART FAILURE, STROKE, ANGINA, ATHEROSCLEROSIS, CEREBRAL AND CARDIAC ISCHAEMIA | PFIZER, INC. (US) | 2000-03-21 | — | — | US | disclosed |