Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 2/20 | 0.34 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8017010 | 0.87 | SRD5A1 (0.41) | SRD5A1SRD5A2 | |
| SCHEMBL8021048 | 0.82 | SRD5A1 (0.34) | SRD5A1SRD5A2NR3C1 | |
| SCHEMBL8023852 | 0.73 | SRD5A1 (0.58) | SRD5A1SRD5A2 | |
| SCHEMBL8023848 | 0.73 | SRD5A1 (0.58) | SRD5A1SRD5A2 | |
| SCHEMBL8006557 | 0.72 | SRD5A1 (0.44) | SRD5A1SRD5A2 | |
| SCHEMBL8016913 | 0.71 | SRD5A1 (0.43) | SRD5A1 | |
| SCHEMBL8006971 | 0.70 | SRD5A1 (0.39) | SRD5A1SRD5A2 | |
| SCHEMBL8018781 | 0.70 | MAPT (0.38) | SRD5A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8016758 | 0.70 | MBOAT4 (0.37) | NR3C1 | |
| SCHEMBL8020895 | 0.69 | SRD5A2 (0.61) | SRD5A1SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0664812-B1 | 17-BETA-ARYL ESTER CARBOXYLATES OF 4-AZA-5-ALPHA-ANDROSTANE-3-ONES | MERCK & CO INC (US) | 2000-01-05 | — | — | EP | disclosed |
| US-5278159-A | Steroid enzyme inhibitor | MERCK & CO., INC. (US) | 1994-01-11 | — | — | US | disclosed |