Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2873080 | 0.82 | HSD11B1 (0.49) | HSD11B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4083045 | 0.82 | HSD11B1 (0.49) | HSD11B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8021550 | 0.78 | PSEN1 (0.47) | HSD11B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8023232 | 0.74 | PSEN1 (0.49) | HSD11B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12197802 | 0.72 | — | — | |
| SCHEMBL8038056 | 0.71 | HSD11B1 (0.40) | HSD11B1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL14757380 | 0.70 | — | — | |
| SCHEMBL22365098 | 0.70 | — | — | |
| SCHEMBL14870537 | 0.70 | PSEN1 (0.56) | HSD11B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4298912 | 0.68 | HSD11B1 (0.45) | HSD11B1PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009108766-A1 | GAMMA SECRETASE MODULATORS FOR THE TREATMENT OF ALZHEIMER ' S DISEASE | SCHERING CORPORATION (US) | 2009-09-03 | — | — | WO | disclosed |