Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 10/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2873080 | 1.00 | HSD11B1 (0.49) | HSD11B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL26100521 | 0.84 | LMNA (0.37) | HSD11B1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL10672122 | 0.83 | CHRM2 (0.49) | HSD11B1CYP3A4CYP2C9CYP2C19KCNH2 | |
| SCHEMBL16070776 | 0.83 | CHRM2 (0.49) | HSD11B1CYP3A4CYP2C9CYP2C19KCNH2 | |
| SCHEMBL19741641 | 0.83 | CHRM2 (0.49) | HSD11B1CYP3A4CYP2C9CYP2C19KCNH2 | |
| SCHEMBL12860114 | 0.83 | PDE2A (0.36) | HSD11B1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL8021178 | 0.82 | HSD11B1 (0.44) | HSD11B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12860115 | 0.81 | HSD11B1 (0.36) | HSD11B1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL8153816 | 0.81 | HSD11B1 (0.38) | HSD11B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8023232 | 0.79 | PSEN1 (0.49) | HSD11B1PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2147917-A1 | ONE-POT PRODUCTION PROCESS FOR CINNAMIDE DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2010-01-27 | — | — | EP | disclosed |
| US-20090270623-A1 | PROCESS FOR PRODUCTION OF CINNAMIDE DERIVATIVE | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-10-29 | — | — | US | disclosed |
| US-20090270623-A1 | PROCESS FOR PRODUCTION OF CINNAMIDE DERIVATIVE | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-10-29 | — | — | US | disclosed |
| US-20090203697-A1 | HETEROCYCLIC TYPE CINNAMIDE DERIVATIVE | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-08-13 | — | — | US | disclosed |
| EP-2019094-A1 | HETEROCYCLIC TYPE CINNAMIDE DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2009-01-28 | — | — | EP | disclosed |
| US-20080306272-A1 | ONE-POT METHODS FOR PREPARING CINNAMIDE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-12-11 | — | — | US | disclosed |
| US-20080306272-A1 | ONE-POT METHODS FOR PREPARING CINNAMIDE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-12-11 | — | — | US | disclosed |
| EP-1950211-A1 | PROCESS FOR PRODUCTION OF CINNAMAMIDE DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2008-07-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270623-A1 | PROCESS FOR PRODUCTION OF CINNAMIDE DERIVATIVE | CBR1, H1-0, CBR3 | HSD11B1 495/4885PSEN1 4651/4885PSEN2 4686/4885 |
| US-20080306272-A1 | ONE-POT METHODS FOR PREPARING CINNAMIDE DERIVATIVES | TAS2R41, TAS2R1, CUL1 | HSD11B1 1762/4885PSEN1 4343/4885PSEN2 4645/4885 |
| US-20090203697-A1 | HETEROCYCLIC TYPE CINNAMIDE DERIVATIVE | CLIC4, NR3C2, MAN2B1 | HSD11B1 194/4885PSEN1 4408/4885PSEN2 4590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.