Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 4/20 | 0.54 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1162443 | 0.85 | FFAR1 (0.45) | KIF11CYP19A1PGR | |
| SCHEMBL29518342 | 0.85 | FFAR1 (0.45) | KIF11CYP19A1PGR | |
| SCHEMBL8026801 | 0.80 | KIF11 (0.44) | KIF11CYP11B1CYP11B2PTGS1 | |
| SCHEMBL3997043 | 0.79 | MMP3 (0.46) | KIF11MMP3CYP11B2HRH3 | |
| SCHEMBL397141 | 0.78 | KIF11 (0.61) | KIF11MMP3CYP11B1CYP11B2PDK2 | |
| SCHEMBL29064768 | 0.78 | KIF11 (0.43) | KIF11CYP11B1CYP11B2 | |
| SCHEMBL2786052 | 0.77 | KIF11 (0.59) | KIF11MMP3CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL9063141 | 0.77 | KIF11 (0.59) | KIF11MMP3CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL30738909 | 0.76 | KIF11 (0.48) | KIF11MMP3CYP11B1CYP11B2HRH3 | |
| SCHEMBL14525324 | 0.76 | KIF11 (0.46) | KIF11MMP3CYP11B1CYP11B2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071504-A1 | 2,6-DISUBSTITUTED PYRIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |