Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.52 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.51 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 2/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
| ▸ | RXRA | P19793 | 2/20 | 0.42 |
| ▸ | RXRB | P28702 | 2/20 | 0.42 |
| ▸ | RXRG | P48443 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8021656 | 0.88 | S1PR1 (0.50) | S1PR1PDCD1CD274HTR2AHTR2C | |
| SCHEMBL7943341 | 0.83 | PDCD1 (0.52) | PDCD1CD274KIF11 | |
| SCHEMBL4050630 | 0.79 | PDCD1 (0.52) | PDCD1CD274PDE4APDE4BPDE4C | |
| SCHEMBL31321848 | 0.76 | PDCD1 (0.46) | PDCD1CD274HTR2APDE4APDE4B | |
| SCHEMBL1437536 | 0.76 | S1PR1 (0.58) | S1PR1HTR2AHTR2CRXRARXRB | |
| SCHEMBL31435356 | 0.76 | S1PR1 (0.58) | S1PR1HTR2AHTR2CRXRARXRB | |
| SCHEMBL6498758 | 0.76 | PDCD1 (0.46) | PDCD1CD274HTR2APDE4APDE4B | |
| SCHEMBL6497164 | 0.76 | PDCD1 (0.62) | PDCD1CD274PDE4APDE4BPDE4C | |
| SCHEMBL28744670 | 0.76 | ABCB1 (0.50) | S1PR1CTSSCTSKRXRARXRB | |
| SCHEMBL8028294 | 0.76 | PDCD1 (0.58) | PDCD1CD274PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071504-A1 | 2,6-DISUBSTITUTED PYRIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |