Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 2/20 | 0.58 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.58 |
| ▸ | APLNR | P35414 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | ERN1 | O75460 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6497164 | 0.86 | PDCD1 (0.62) | PDCD1CD274SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL238087 | 0.85 | APLNR (0.63) | PDCD1CD274APLNRKDM4EALDH1A1 | |
| SCHEMBL8012943 | 0.84 | PDCD1 (0.43) | PDCD1CD274NPC1TP53MAPK1 | |
| SCHEMBL8017682 | 0.83 | CYP2C9 (0.46) | PDCD1CD274NPC1TP53MAPK1 | |
| SCHEMBL3994452 | 0.82 | RAB9A (0.47) | PDCD1CD274NPC1TP53MAPK1 | |
| SCHEMBL8017441 | 0.81 | PDCD1 (0.61) | PDCD1CD274APLNRSMN1; SMN2KDM4E | |
| SCHEMBL2293149 | 0.81 | RAB9A (0.46) | NPC1TP53MAPK1CASP3RAB9A | |
| SCHEMBL7943341 | 0.80 | PDCD1 (0.52) | PDCD1CD274ALDH1A1HPGDMEN1 | |
| Methylene Chloride SCHEMBL28275708 | 0.80 | APLNR (0.58) | PDCD1CD274APLNRKDM4EALDH1A1 | |
| SCHEMBL8024217 | 0.80 | PDCD1 (0.56) | PDCD1CD274APLNRMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071504-A1 | 2,6-DISUBSTITUTED PYRIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |