Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.39 |
| ▸ | SSTR2 | P30874 | 2/20 | 0.37 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | MC5R | P33032 | 1/20 | 0.36 |
| ▸ | MC3R | P41968 | 1/20 | 0.36 |
| ▸ | MC1R | Q01726 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8033335 | 0.81 | TLR8 (0.47) | MTNR1ATLR8SSTR2SSTR4CYP1A2 | |
| SCHEMBL8021660 | 0.79 | TLR8 (0.49) | MTNR1ATLR8CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL8031004 | 0.78 | TLR8 (0.51) | MTNR1ATLR8CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL8034939 | 0.77 | TLR8 (0.56) | TLR8 | |
| SCHEMBL8021705 | 0.76 | TLR8 (0.55) | TLR8 | |
| SCHEMBL8033115 | 0.74 | CYP2A6 (0.50) | NQO2MTNR1AMTNR1BTLR8SSTR2 | |
| SCHEMBL10344605 | 0.73 | S1PR1 (0.43) | TLR8CNR1CNR2 | |
| SCHEMBL16487341 | 0.73 | ALDH1A1 (0.50) | XDHCYP1A2MAPTCYP3A4CYP2D6 | |
| SCHEMBL127566 | 0.72 | HTR1B (0.52) | NQO2MTNR1ATLR8SSTR2SSTR4 | |
| SCHEMBL15345359 | 0.72 | TLR8 (0.49) | MTNR1ATLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745586-B1 | Aryl(alkyl) propylamides, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-03-08 | — | — | EP | disclosed |
| US-5760071-A | AN UREA OR THIOUREA COMPOUNDS FOR TREATING MELATONINERGIC SYSTEM DISORDER, SLEEP DISORDER | ADIR ET COMPAGNIE (FR) | 1998-06-02 | — | — | US | disclosed |
| US-5731352-A | THERAPY FOR DISORDERS OF THE MELATONINERGIC SYSTEM | ADIR ET COMPAGNIE (FR) | 1998-03-24 | — | — | US | disclosed |
| EP-0745586-A1 | Aryl(alkyl) propylamides, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-12-04 | — | — | EP | disclosed |