Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 11/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8034939 | 0.96 | TLR8 (0.56) | TLR8HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL8021705 | 0.94 | TLR8 (0.55) | TLR8HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL8521394 | 0.93 | HTR1A (0.55) | TLR8HTR1AHTR1DHTR1BMTNR1A | |
| SCHEMBL8021660 | 0.93 | TLR8 (0.49) | TLR8HTR1AHTR1DHTR1BCYP1A2 | |
| SCHEMBL11229923 | 0.92 | MTNR1A (0.44) | HTR1ACYP1A2CYP2D6CYP2C19MTNR1A | |
| SCHEMBL15345359 | 0.88 | TLR8 (0.49) | TLR8HTR1AMTNR1A | |
| SCHEMBL15345431 | 0.88 | HTR1A (0.46) | TLR8HTR1AHTR1DHTR1BCYP1A2 | |
| SCHEMBL8033335 | 0.88 | TLR8 (0.47) | TLR8HTR1AHTR1DHTR1BCYP1A2 | |
| SCHEMBL30589485 | 0.88 | TLR8 (0.46) | TLR8HTR1AHTR1DHTR1BMTNR1A | |
| SCHEMBL9770069 | 0.86 | TLR8 (0.47) | TLR8HTR1AHTR1DHTR1BMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745586-B1 | Aryl(alkyl) propylamides, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-03-08 | — | — | EP | disclosed |
| US-5760071-A | AN UREA OR THIOUREA COMPOUNDS FOR TREATING MELATONINERGIC SYSTEM DISORDER, SLEEP DISORDER | ADIR ET COMPAGNIE (FR) | 1998-06-02 | — | — | US | disclosed |
| US-5731352-A | THERAPY FOR DISORDERS OF THE MELATONINERGIC SYSTEM | ADIR ET COMPAGNIE (FR) | 1998-03-24 | — | — | US | disclosed |
| EP-0745586-A1 | Aryl(alkyl) propylamides, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-12-04 | — | — | EP | disclosed |