Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.54 |
| ▸ | CA12 | O43570 | 5/20 | 0.42 |
| ▸ | CA1 | P00915 | 5/20 | 0.42 |
| ▸ | CA9 | Q16790 | 4/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ZDHHC20 | Q5W0Z9 | 2/20 | 0.35 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14755630 | 0.96 | CA14 (0.54) | CA14CA12CA1CA9HDAC1 | |
| SCHEMBL1962811 | 0.94 | CA14 (0.55) | CA14CA12CA1CA9HDAC1 | |
| SCHEMBL136485 | 0.94 | CA14 (0.55) | CA14CA12CA1CA9HDAC1 | |
| SCHEMBL133198 | 0.94 | CA14 (0.55) | CA14CA12CA1CA9HDAC1 | |
| SCHEMBL140146 | 0.94 | CA14 (0.55) | CA14CA12CA1CA9HDAC1 | |
| SCHEMBL25969918 | 0.94 | CA14 (0.54) | CA14CA12CA1CA9HDAC1 | |
| SCHEMBL18163279 | 0.91 | CA14 (0.53) | CA14CA12CA1CA9HDAC1 | |
| SCHEMBL26616523 | 0.91 | CA14 (0.53) | CA14CA12CA1CA9HDAC1 | |
| SCHEMBL8285770 | 0.91 | CA14 (0.51) | CA14CA12CA1CA9HDAC1 | |
| SCHEMBL10226271 | 0.90 | CA14 (0.49) | CA14CA12CA1CA9HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6114394-A | Polyamine derivatives as radioprotective agents | MERRELL PHARMACEUTICALS INC. (US) | 2000-09-05 | — | — | US | disclosed |
| EP-0686142-B1 | POLYAMINE DERIVATIVES AS RADIOPROTECTIVE AGENTS | MERRELL PHARMA INC (US) | 1998-12-30 | — | — | EP | disclosed |
| US-5753714-A | ANTIPROTOZOA AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1998-05-19 | — | — | US | disclosed |
| EP-0686142-A1 | POLYAMINE DERIVATIVES AS RADIOPROTECTIVE AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1995-12-13 | — | — | EP | disclosed |
| WO-1994019311-A1 | POLYAMINE DERIVATIVES AS RADIOPROTECTIVE AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-09-01 | — | — | WO | disclosed |
| EP-0277635-B1 | Novel polyamine derivatives | MERRELL DOW PHARMA (US) | 1994-01-05 | — | — | EP | disclosed |
| EP-0277635-A2 | Novel polyamine derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-08-10 | — | — | EP | disclosed |