Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 7/20 | 0.72 |
| ▸ | MAPT | P10636 | 5/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | TNF | P01375 | 3/20 | 0.58 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.58 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | PDE6D | O43924 | 1/20 | 0.55 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.55 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8025719 | 0.89 | TP53 (0.67) | TP53MAPTALDH1A1KDM4EALOX5AP | |
| SCHEMBL8022230 | 0.88 | TP53 (0.74) | TP53MAPTALDH1A1KDM4EALOX5AP | |
| SCHEMBL8022210 | 0.85 | TP53 (0.68) | TP53MAPTALDH1A1KDM4EGAA | |
| SCHEMBL8023982 | 0.85 | TP53 (0.68) | TP53MAPTALDH1A1GAAPDE6D | |
| SCHEMBL29412044 | 0.84 | TP53 (1.00) | TP53MAPTALDH1A1KDM4ETNF | |
| SCHEMBL8022045 | 0.83 | TP53 (0.82) | TP53MAPTALDH1A1KDM4ETNF | |
| SCHEMBL8021682 | 0.82 | TP53 (0.77) | TP53MAPTALDH1A1KDM4EGAA | |
| SCHEMBL8027160 | 0.81 | TP53 (0.83) | TP53MAPTALDH1A1KDM4EPDE6D | |
| SCHEMBL8024166 | 0.80 | KDM4E (0.56) | TP53MAPTALDH1A1KDM4ETNF | |
| SCHEMBL28322549 | 0.80 | MAPT (0.66) | TP53MAPTALDH1A1KDM4ETNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030992-A | ANTAGONISTS FOR THE BINDING OF NEUROKININ-2 RECEPTOR; SLEEP DISORDERS; BENZIMIDES, 2- OR 3-ALKOXYBENZIMIDES AND 2,3-DIALKOXYBENZIMIDES | ELI LILLY AND COMPANY (US) | 2000-02-29 | — | — | US | disclosed |
| US-6025379-A | A SUBSTITUTED BENZIMIDAZOLE, TACHYKININ RECEPTOR ANTAGONISTS, | ELI LILLY AND COMPANY (US) | 2000-02-15 | — | — | US | disclosed |
| WO-1997031635-A1 | METHODS OF TREATING OR PREVENTING SLEEP APNEA | ELI LILLY AND COMPANY (US) | 1997-09-04 | — | — | WO | disclosed |
| US-5552426-A | NERVOUS SYSTEM DISORDERS USING IMIDAZOLE DERIVITIVES | ELI LILLY AND COMPANY (US) | 1996-09-03 | — | — | US | disclosed |
| EP-0694535-A1 | Non-peptidyl tachykinin receptor antagonists | ELI LILLY AND COMPANY (US) | 1996-01-31 | — | — | EP | disclosed |