Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.82 |
| ▸ | MAPT | P10636 | 5/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | GALR3 | O60755 | 1/20 | 0.64 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | PDE6D | O43924 | 1/20 | 0.63 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.63 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | DRD2 | P14416 | 1/20 | 0.60 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | CNR2 | P34972 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | TNF | P01375 | 1/20 | 0.57 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29412044 | 0.91 | TP53 (1.00) | TP53MAPTALDH1A1PDE6DALDH2 | |
| SCHEMBL8027160 | 0.90 | TP53 (0.83) | TP53MAPTALDH1A1PDE6DALDH2 | |
| SCHEMBL8021682 | 0.89 | TP53 (0.77) | TP53MAPTALDH1A1PDE6DALDH2 | |
| SCHEMBL8027362 | 0.86 | KDM4E (0.79) | TP53MAPTALDH1A1RAB9APDE6D | |
| SCHEMBL28261637 | 0.86 | ALDH1A1 (0.91) | TP53MAPTALDH1A1GALR3NR2F2 | |
| SCHEMBL8025719 | 0.85 | TP53 (0.67) | TP53MAPTALDH1A1PDE6DALDH2 | |
| SCHEMBL8022230 | 0.84 | TP53 (0.74) | TP53MAPTALDH1A1PDE6DALDH2 | |
| SCHEMBL29412062 | 0.84 | TP53 (0.78) | TP53MAPTALDH1A1PDE6DALDH2 | |
| SCHEMBL8022017 | 0.83 | TP53 (0.72) | TP53MAPTALDH1A1PDE6DALDH2 | |
| SCHEMBL28322548 | 0.83 | TP53 (0.71) | TP53MAPTALDH1A1PDE6DALDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030992-A | ANTAGONISTS FOR THE BINDING OF NEUROKININ-2 RECEPTOR; SLEEP DISORDERS; BENZIMIDES, 2- OR 3-ALKOXYBENZIMIDES AND 2,3-DIALKOXYBENZIMIDES | ELI LILLY AND COMPANY (US) | 2000-02-29 | — | — | US | disclosed |
| US-6025379-A | A SUBSTITUTED BENZIMIDAZOLE, TACHYKININ RECEPTOR ANTAGONISTS, | ELI LILLY AND COMPANY (US) | 2000-02-15 | — | — | US | disclosed |
| WO-1997033873-A1 | METHODS OF TREATING OR PREVENTING INTERSTITIAL CYSTITIS | ELI LILLY AND COMPANY (US) | 1997-09-18 | — | — | WO | disclosed |
| WO-1997031635-A1 | METHODS OF TREATING OR PREVENTING SLEEP APNEA | ELI LILLY AND COMPANY (US) | 1997-09-04 | — | — | WO | disclosed |
| US-5552426-A | NERVOUS SYSTEM DISORDERS USING IMIDAZOLE DERIVITIVES | ELI LILLY AND COMPANY (US) | 1996-09-03 | — | — | US | disclosed |
| EP-0694535-A1 | Non-peptidyl tachykinin receptor antagonists | ELI LILLY AND COMPANY (US) | 1996-01-31 | — | — | EP | disclosed |