Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 4/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.50 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | HRH1 | P35367 | 3/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21226500 | 0.87 | SLC6A9 (0.49) | SLC6A9ADRA2BADRA2AADRA2CALDH1A1 | |
| SCHEMBL21103400 | 0.81 | SLC6A9 (0.44) | SLC6A4HRH3SLC6A9 | |
| SCHEMBL8011828 | 0.81 | SLC6A4 (0.66) | SLC6A4HRH3HTR2AHRH1ADRA2B | |
| SCHEMBL8011824 | 0.81 | SLC6A4 (0.66) | SLC6A4HRH3HTR2AHRH1ADRA2B | |
| SCHEMBL7169436 | 0.80 | SLC6A4 (0.52) | SLC6A4HRH3SLC6A9HTR2AHRH1 | |
| SCHEMBL6729778 | 0.80 | SLC6A9 (0.64) | SLC6A4HRH3SLC6A9HTR2AHRH1 | |
| SCHEMBL3894545 | 0.80 | CYP2D6 (0.64) | SLC6A4HRH3SLC6A9HTR2AHRH1 | |
| SCHEMBL8197707 | 0.80 | CYP2D6 (0.64) | SLC6A4HRH3SLC6A9HTR2AHRH1 | |
| SCHEMBL8024681 | 0.78 | SLC6A4 (0.53) | SLC6A4HRH3SLC6A9HTR2AHRH1 | |
| SCHEMBL17880600 | 0.78 | SLC6A4 (0.45) | SLC6A4HRH3SLC6A9HTR2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000058262-A1 | STEREOSPECIFIC METHOD FOR PREPARING TOMOXETINE AND INTERMEDIATES THEREOF | ELI LILLY AND COMPANY (US) | 2000-10-05 | — | — | WO | claimed |
| WO-2000058262-A1 | STEREOSPECIFIC METHOD FOR PREPARING TOMOXETINE AND INTERMEDIATES THEREOF | ELI LILLY AND COMPANY (US) | 2000-10-05 | — | — | WO | disclosed |