Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 3/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.44 |
| ▸ | F9 | P00740 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | NMT1 | P30419 | 4/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | NMT2 | O60551 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GABRP | O00591 | 1/20 | 0.42 |
| ▸ | GABRD | O14764 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8024530 | 0.83 | F9 (0.48) | MMP13GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL8010798 | 0.83 | HPGD (0.53) | MMP13F9F10MEN1KMT2A | |
| SCHEMBL8024562 | 0.82 | MMP13 (0.46) | MMP13GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL8010359 | 0.80 | MMP13 (0.43) | MMP13GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL8024886 | 0.78 | MMP13 (0.48) | MMP13GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL8027254 | 0.78 | MMP13 (0.44) | MMP13GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL8024355 | 0.77 | F9 (0.44) | MMP13GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL8021222 | 0.77 | MMP13 (0.42) | MMP13GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL8021187 | 0.76 | DYRK1A (0.53) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10953368 | 0.76 | F9 (0.51) | F9F10HPGDMAOADYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6040309-A | ACTIVE MATERIAL TREATING OF RESTENOSIS, RENAL FAILURE, PULMONARY HYPERTENSION, BENIGN PROSTATIC HYPERTROPHY, MALE ERECTILE DYSFUNCTION, CONGESTIVE HEART FAILURE, STROKE, ANGINA, ATHEROSCLEROSIS, CEREBRAL AND CARDIAC ISCHAEMIA | PFIZER, INC. (US) | 2000-03-21 | — | — | US | disclosed |