Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.60 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.52 |
| ▸ | BCL2 | P10415 | 2/20 | 0.47 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8037140 | 0.91 | PTGS2 (0.61) | PTGS2 | |
| SCHEMBL8033502 | 0.89 | PTGS2 (0.75) | PTGS2ALOX5 | |
| SCHEMBL8033132 | 0.87 | PTGS2 (0.81) | PTGS2 | |
| SCHEMBL8023278 | 0.81 | PTGS2 (0.72) | PTGS2ALOX5ALDH1A1HPGD | |
| SCHEMBL8035500 | 0.80 | PTGS2 (0.58) | PTGS2ALOX5 | |
| SCHEMBL8032930 | 0.80 | PTGS2 (0.75) | PTGS2 | |
| SCHEMBL8023451 | 0.77 | PTGS2 (0.84) | PTGS2 | |
| SCHEMBL8037107 | 0.77 | PTGS2 (0.76) | PTGS2 | |
| SCHEMBL8033665 | 0.76 | PTGS2 (0.81) | PTGS2 | |
| SCHEMBL8039677 | 0.76 | PTGS2 (0.66) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000066562-A1 | PYRAZOLES HAVING ANTIINFLAMMATORY ACTIVITY | DR. REDDY'S RESEARCH FOUNDATION (IN) | 2000-11-09 | — | — | WO | claimed |
| WO-2000066562-A1 | PYRAZOLES HAVING ANTIINFLAMMATORY ACTIVITY | DR. REDDY'S RESEARCH FOUNDATION (IN) | 2000-11-09 | — | — | WO | disclosed |