Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.54 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.54 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8986018 | 0.88 | OPRM1 (0.50) | OPRM1OPRL1OPRD1OPRK1MEN1 | |
| SCHEMBL28914563 | 0.85 | OPRM1 (0.69) | OPRM1OPRL1OPRD1OPRK1HSD17B3 | |
| SCHEMBL17493640 | 0.83 | OPRM1 (0.58) | OPRM1OPRL1OPRD1OPRK1MEN1 | |
| SCHEMBL4989701 | 0.83 | OPRM1 (0.58) | OPRM1OPRL1OPRD1OPRK1MEN1 | |
| SCHEMBL22355057 | 0.82 | FOLH1 (0.46) | OPRM1OPRL1L3MBTL1CYP2C9KMT2A | |
| Hydrochloric Acid SCHEMBL27656058 | 0.81 | OPRM1 (0.59) | OPRM1OPRL1OPRD1OPRK1MEN1 | |
| SCHEMBL14379186 | 0.81 | OPRL1 (0.50) | OPRM1OPRL1OPRD1OPRK1MEN1 | |
| SCHEMBL4204848 | 0.81 | OPRM1 (0.60) | OPRM1OPRL1OPRD1OPRK1GRIN2B | |
| SCHEMBL5672427 | 0.76 | OPRM1 (0.55) | OPRM1OPRL1OPRD1OPRK1MEN1 | |
| SCHEMBL8410043 | 0.76 | OPRM1 (0.55) | OPRM1OPRL1OPRD1OPRK1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780369-B1 | 1-Phenyl-2-dimethylaminomethyl-cyclohexan-1-ol derivatives as pharmaceutical agents | GRUENENTHAL GMBH (DE) | 2000-01-19 | — | — | EP | disclosed |
| US-5801201-A | 1-phenyl-2-dimenthylaminomethyl-cyclohexan-1-ol compounds as pharmaceutical active ingredients | GRUENENTHAL GMBH (DE) | 1998-09-01 | — | — | US | disclosed |
| EP-0780369-A1 | 1-Phenyl-2-dimethylaminomethyl-cyclohexan-1-ol derivatives as pharmaceutical agents | Grünenthal GmbH (DE) | 1997-06-25 | — | — | EP | disclosed |