Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM7 | Q14831 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8017767 | 0.83 | OPRM1 (0.60) | GRM7SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL8017685 | 0.81 | OPRM1 (0.64) | GRM7SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL19910587 | 0.78 | NOTUM (0.63) | GRM7SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL18823655 | 0.77 | GRM7 (0.62) | GRM7SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL3089154 | 0.76 | SMN1; SMN2 (0.68) | GRM7SMN1; SMN2ALDH1A1KDM4EPOLB | |
| SCHEMBL30253474 | 0.76 | SMN1; SMN2 (0.68) | GRM7SMN1; SMN2ALDH1A1KDM4EPOLB | |
| SCHEMBL8024012 | 0.76 | OPRM1 (0.69) | SMN1; SMN2MEN1KMT2AALDH1A1HTT | |
| SCHEMBL19910611 | 0.76 | GRM7 (0.60) | GRM7SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL8017929 | 0.75 | TSHR (0.51) | SMN1; SMN2MEN1KMT2AALDH1A1OPRM1 | |
| Bromide SCHEMBL8668237 | 0.74 | SMN1; SMN2 (0.66) | GRM7SMN1; SMN2ALDH1A1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6114381-A | TO CONTROL BRAIN DAMAGE ASSOCIATED WITH ANOXIA OR ISCHEMIA WHICH TYPICALLY FOLLOWS STROKE, CARDIAC ARREST OR PERINATAL ASPHYXIA; COMPOUND IS AN ANTAGONIST TO INHIBIT EXCITOTOXIC ACTIONS AT EXCITATORY AMINO ACID RECEPTOR SITES | G. D. SEARLE & CO. (US) | 2000-09-05 | — | — | US | disclosed |