Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.69 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.69 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.69 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2374151 | 0.83 | TSHR (0.67) | OPRM1OPRD1OPRK1HDAC8MEN1 | |
| SCHEMBL2374156 | 0.83 | TSHR (0.67) | OPRM1OPRD1OPRK1HDAC8MEN1 | |
| SCHEMBL8017504 | 0.82 | OPRK1 (0.77) | OPRM1OPRD1OPRK1MEN1KMT2A | |
| SCHEMBL8019695 | 0.81 | OPRK1 (1.00) | OPRM1OPRD1OPRK1MEN1KMT2A | |
| SCHEMBL8017684 | 0.81 | OPRK1 (1.00) | OPRM1OPRD1OPRK1MEN1KMT2A | |
| SCHEMBL8007390 | 0.81 | OPRK1 (1.00) | OPRM1OPRD1OPRK1MEN1KMT2A | |
| SCHEMBL26982499 | 0.79 | FPR1 (0.60) | OPRM1OPRD1OPRK1HDAC8MEN1 | |
| SCHEMBL27126281 | 0.79 | FPR1 (0.60) | OPRM1OPRD1OPRK1HDAC8MEN1 | |
| SCHEMBL10422952 | 0.76 | KMT2A (0.65) | OPRM1OPRD1OPRK1MEN1KMT2A | |
| SCHEMBL10422953 | 0.76 | KMT2A (0.65) | OPRM1OPRD1OPRK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6114381-A | TO CONTROL BRAIN DAMAGE ASSOCIATED WITH ANOXIA OR ISCHEMIA WHICH TYPICALLY FOLLOWS STROKE, CARDIAC ARREST OR PERINATAL ASPHYXIA; COMPOUND IS AN ANTAGONIST TO INHIBIT EXCITOTOXIC ACTIONS AT EXCITATORY AMINO ACID RECEPTOR SITES | G. D. SEARLE & CO. (US) | 2000-09-05 | — | — | US | disclosed |