SCHEMBL8024246

SCHEMBL8024246

Oc1cccc(C2CC2c2ccccc2)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2C P28335 2/20 0.56
HTR2A P28223 1/20 0.56
HTR2B P41595 1/20 0.56
CHRNB4 P30926 1/20 0.53
CHRNA3 P32297 1/20 0.53
KDM1A O60341 4/20 0.47
HDAC6 Q9UBN7 1/20 0.47
PLG P00747 1/20 0.46
PLAU P00749 1/20 0.46
PLAT P00750 1/20 0.46
KLK1 P06870 1/20 0.46
DRD2 P14416 1/20 0.45
MAOA P21397 3/20 0.45
MAOB P27338 3/20 0.45
CYP2C19 P33261 3/20 0.45
CYP2B6 P20813 2/20 0.45
CYP1A2 P05177 2/20 0.45
CYP2D6 P10635 2/20 0.45
CYP2C9 P11712 2/20 0.45
LMNA P02545 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9131533 0.90 HTR2A (0.54) HTR2CHTR2AHTR2BCHRNB4CHRNA3
SCHEMBL9131537 0.90 HTR2A (0.54) HTR2CHTR2AHTR2BCHRNB4CHRNA3
SCHEMBL9134151 0.80 KDM1A (0.52) HTR2CKDM1APLGPLAUPLAT
SCHEMBL9134150 0.80 KDM1A (0.52) HTR2CKDM1APLGPLAUPLAT
SCHEMBL23923444 0.79 HTR2A (0.56) HTR2CHTR2AHTR2BCHRNB4CHRNA3
SCHEMBL23923443 0.79 HTR2A (0.56) HTR2CHTR2AHTR2BCHRNB4CHRNA3
SCHEMBL23940041 0.79 HTR2A (0.56) HTR2CHTR2AHTR2BCHRNB4CHRNA3
SCHEMBL21066331 0.79 KDM1A (0.66) HTR2CHTR2AHTR2BCHRNB4CHRNA3
SCHEMBL30317790 0.79 HTR2A (0.56) HTR2CHTR2AHTR2BCHRNB4CHRNA3
SCHEMBL23923588 0.79 HTR2A (0.56) HTR2CHTR2AHTR2BCHRNB4CHRNA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1107049-C Benzyloxy substituted aromatics and their use as fungicides and insecticides DOW BENEFITING AGRICULTURE CO (US) 2003-04-30 CN disclosed
EP-0889024-B1 Benzyloxy substituted aromatics and their use as fungicides and insecticides ROHM & HAAS (US) 2000-09-13 EP disclosed
US-6114375-A FOR CONTROLLING PHYTOPATHOGENIC FUNGI; METHYL N-ALKOXY-N-(2-((SUBSTITUTED CYCLOPROPYL)PHENOXYMETHYL)PHENYL) CARBAMATE DERIVATIVES ROHM AND HAAS COMPANY (US) 2000-09-05 US disclosed
US-6022891-A Substituted cyclopropyl phenoxymethyl phenyl carbamates and their use as fungicides ROHM AND HAAS COMPANY (US) 2000-02-08 US disclosed
US-5945557-A PHENYL DERIVATIVES WHICH POSSESS A SUBSTITUTED CYCLOPROPYL MOIETY; USEFUL AGAINST POWDERY MILDEW, BLIGHT AND OTHER PLATN DISEASES; INSECTICIDES AGAINST SOUTHERN ARMYWORM, MEXICAN BEAN BEETLE AND SPIDER MITES, FOR EXAMPLE ROHM AND HAAS COMPANY (US) 1999-08-31 US disclosed
EP-0924197-A1 Substituted cyclopropyl phenoxymethyl phenyl carbamates and their use as fungicides ROHM AND HAAS COMPANY (US) 1999-06-23 EP disclosed
CN-1204637-A Benzyloxy substituted aromatics and their use as fungicides and insecticides ROHM & HAAS (US) 1999-01-13 CN disclosed
EP-0889024-A1 Benzyloxy substituted aromatics and their use as fungicides and insecticides ROHM AND HAAS COMPANY (US) 1999-01-07 EP disclosed