Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.52 |
| ▸ | KDM1A | O60341 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 2/20 | 0.44 |
| ▸ | CKS1B | P61024 | 1/20 | 0.43 |
| ▸ | SKP1 | P63208 | 1/20 | 0.43 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8101516 | 0.83 | MEN1 (0.58) | KMT2AMEN1KCNA3KDM1AHSD11B1 | |
| SCHEMBL18836570 | 0.81 | KCNA3 (0.40) | KCNA3KDM1AMAOBJAK2JAK1 | |
| SCHEMBL16905907 | 0.81 | KCNA3 (0.40) | KCNA3KDM1AMAOBJAK2JAK1 | |
| SCHEMBL13688478 | 0.81 | HSD11B1 (0.47) | KMT2AMEN1JAK2JAK1HSD11B1 | |
| SCHEMBL3864735 | 0.80 | MEN1 (0.60) | KMT2AMEN1KDM1AMAOBCTSK | |
| SCHEMBL16897491 | 0.78 | KCNA3 (0.39) | KMT2AMEN1KCNA3KDM1AMAOB | |
| SCHEMBL16905915 | 0.78 | KCNA3 (0.39) | KMT2AMEN1KCNA3KDM1AMAOB | |
| SCHEMBL15167396 | 0.77 | JAK3 (0.40) | KCNA3KDM1AMAOBJAK2JAK1 | |
| SCHEMBL5329140 | 0.76 | HSD11B1 (0.50) | KMT2AMEN1HSD11B1CHRM4NPC1 | |
| SCHEMBL8029953 | 0.74 | MEN1 (0.54) | KMT2AMEN1KDM1AHSD11B1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1014973-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2000-09-20 | — | — | EP | disclosed |
| EP-1014973-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-07-05 | — | — | EP | disclosed |
| US-6057350-A | Alpha 1a adrenergic receptor antagonists | MERCK & CO., INC. (US) | 2000-05-02 | — | — | US | disclosed |
| WO-1998057632-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-12-23 | — | — | WO | disclosed |