SCHEMBL8024653

SCHEMBL8024653

CCCCCO[C@H]1CC[C@H](COc2cc(F)c(C(=O)Oc3cc(F)c(F)c(F)c3)c(F)c2)CC1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACACB O00763 2/20 0.36
PARP10 Q53GL7 2/20 0.35
PARP15 Q460N3 1/20 0.35
EPHX2 P34913 1/20 0.34
THRB P10828 2/20 0.34
CNR2 P34972 8/20 0.33
CNR1 P21554 7/20 0.33
SCN9A Q15858 1/20 0.33
PLA2G2A P14555 1/20 0.33
PDE4A P27815 1/20 0.32
PDE4D Q08499 1/20 0.32
PDE3B Q13370 1/20 0.32
PDE3A Q14432 1/20 0.32
KAT6A Q92794 1/20 0.32
NPC1 O15118 1/20 0.32
LMNA P02545 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C9 P11712 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8024655 1.00 ACACB (0.36) ACACBPARP10PARP15EPHX2THRB
SCHEMBL8028056 0.99 ACACB (0.36) ACACBPARP10PARP15EPHX2THRB
SCHEMBL8028059 0.99 ACACB (0.36) ACACBPARP10PARP15EPHX2THRB
SCHEMBL8028007 0.97 PARP10 (0.38) ACACBPARP10PARP15SCN9APDE4A
SCHEMBL8028009 0.97 PARP10 (0.38) ACACBPARP10PARP15SCN9APDE4A
SCHEMBL8022521 0.93 ACACB (0.38) ACACBPARP10PARP15SCN9AKAT6A
SCHEMBL8022517 0.93 ACACB (0.38) ACACBPARP10PARP15SCN9AKAT6A
SCHEMBL8022362 0.89 PLA2G2A (0.34) ACACBPARP10PARP15EPHX2THRB
SCHEMBL8024818 0.87 PARP10 (0.37) PARP10PARP15THRBSCN9AKAT6A
SCHEMBL8024815 0.87 PARP10 (0.37) PARP10PARP15THRBSCN9AKAT6A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6149990-A Carboxylate derivatives comprising an ether group and liquid crystal composition comprising the same CHISSO CORPORATION (JP) 2000-11-21 US disclosed
EP-0884302-A1 CARBOXYLIC ESTER DERIVATIVES CONTAINING ETHER GROUP AND LIQUID-CRYSTAL COMPOSITION CONTAINING THE SAME CHISSO CORPORATION (JP) 1998-12-16 EP disclosed