SCHEMBL8024762

SCHEMBL8024762

CC(F)c1ncnc(NC(C)c2ccc(OC(F)(F)F)cc2)c1Cl

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATP1A1 P05023 1/20 0.42
ATP1B1 P05026 1/20 0.42
ATP1A3 P13637 1/20 0.42
ATP1B2 P14415 1/20 0.42
ATP1A2 P50993 1/20 0.42
ATP1B3 P54709 1/20 0.42
FXYD2 P54710 1/20 0.42
ATP1A4 Q13733 1/20 0.42
EGFR P00533 3/20 0.41
CNR1 P21554 1/20 0.40
CNR2 P34972 1/20 0.40
AURKA O14965 2/20 0.40
PDPK1 O15530 1/20 0.39
RPS6KB1 P23443 1/20 0.39
ALDH1A1 P00352 2/20 0.39
ABL1 P00519 2/20 0.38
BCR P11274 2/20 0.38
IDH1 O75874 2/20 0.37
TTBK1 Q5TCY1 1/20 0.37
TTBK2 Q6IQ55 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9403593 0.91 AURKA (0.41) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
SCHEMBL8024930 0.86 EGFR (0.48) EGFRCNR1CNR2AURKARPS6KB1
SCHEMBL8024509 0.85 EGFR (0.40) EGFRCNR1CNR2IDH1PDE2A
SCHEMBL8024317 0.81 EGFR (0.49) EGFRCNR1CNR2GALR3NR2F2
SCHEMBL7173840 0.80 GALR3 (0.55) EGFRGALR3NR2F2
SCHEMBL7173843 0.80 GALR3 (0.55) EGFRGALR3NR2F2
SCHEMBL7173846 0.80 GALR3 (0.55) EGFRGALR3NR2F2
SCHEMBL8028223 0.80 GALR3 (0.55) EGFRGALR3NR2F2
SCHEMBL8014117 0.79 GALR3 (0.38) EGFRCNR1CNR2P2RX3GALR3
SCHEMBL9403591 0.78 EGFR (0.39) EGFRCNR1CNR2IDH1PDE2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0543402-B1 Aralkylaminopyrimidine derivative, method for preparing the same and composition for controlling noxious organisms UBE INDUSTRIES (JP) 2000-03-01 EP claimed
US-5280025-A Aralkylaminopyrimidine derivative, and chemical for controlling noxious organisms containing the same UBE INDUSTRIES, LTD. (JP) 1994-01-18 US claimed
EP-0543402-A1 Aralkylaminopyrimidine derivative, method for preparing the same and chemical for controlling noxious organisms containing the same UBE INDUSTRIES, LTD. (JP) 1993-05-26 EP claimed