SCHEMBL8024809

SCHEMBL8024809

CC(C)(NC(=O)c1ccc([N+](=O)[O-])cc1)C(=O)CCl

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 6/20 0.50
RAB9A P51151 5/20 0.50
SMN1; SMN2 Q16637 3/20 0.50
HDAC3 O15379 1/20 0.50
HDAC1 Q13547 1/20 0.50
HDAC2 Q92769 1/20 0.50
TAAR1 Q96RJ0 1/20 0.50
MAPT P10636 6/20 0.49
MEN1 O00255 4/20 0.47
KMT2A Q03164 4/20 0.47
ALDH1A1 P00352 4/20 0.47
TP53 P04637 1/20 0.47
GAA P10253 1/20 0.47
POLB P06746 2/20 0.47
TMEM97 Q5BJF2 1/20 0.46
SIGMAR1 Q99720 1/20 0.46
MAPK1 P28482 1/20 0.46
ALOX12 P18054 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
MITF O75030 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8048504 0.85 HDAC3 (0.53) NPC1RAB9ASMN1; SMN2HDAC3HDAC1
SCHEMBL28454641 0.82 TDP1 (0.53) NPC1RAB9ASMN1; SMN2HDAC3HDAC1
SCHEMBL1857541 0.80 MAPK1 (0.56) RAB9AHDAC3HDAC1HDAC2MAPT
SCHEMBL689308 0.79 SMN1; SMN2 (0.64) NPC1RAB9ASMN1; SMN2HDAC3HDAC1
SCHEMBL5507071 0.78 ALDH1A1 (0.54) NPC1RAB9ASMN1; SMN2HDAC3HDAC1
SCHEMBL1761409 0.77 POLB (0.52) NPC1RAB9ASMN1; SMN2MAPTMEN1
SCHEMBL689307 0.75 HDAC3 (0.58) NPC1RAB9ASMN1; SMN2HDAC3HDAC1
SCHEMBL5610870 0.74 MAPT (0.68) NPC1RAB9ASMN1; SMN2HDAC3HDAC1
SCHEMBL6778570 0.74 MEN1 (0.53) NPC1RAB9AHDAC3HDAC1HDAC2
SCHEMBL29082695 0.74 RAB9A (0.52) NPC1RAB9ASMN1; SMN2HDAC3HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6147220-A Process to 5-methyleneoxazolines ROHM AND HAAS COMPANY (US) 2000-11-14 US disclosed
US-5977368-A Process to chloroketones using oxazolines ROHM AND HAAS COMPANY (US) 1999-11-02 US disclosed
US-5959114-A CYCLIZING AN ALKYNYLAMIDO USING AN ACID ROHM AND HAAS COMPANY (US) 1999-09-28 US disclosed
US-5942621-A CYCLIZING AN ALKYNYL AMIDE USING A MILD AQUEOUS BASE IN THE PRESENCE OF AN ORGANIC SOLVENT AND PHASE TRANSFER AGENT TO YIELD A 5-METHYLENEOXAZOLINE CHEMICAL INTERMEDIATE TO COST EFFICIENT ALPHA-CHLOROKETONE FUNGICIDE PRODUCTION ROHM AND HAAS COMPANY (US) 1999-08-24 US disclosed
US-5936096-A TRICHLOROISOCYANURIC ACID USED AS SELECTIVE CHLORINATION REAGENT IN THE CHLORINATION OF A 5-METHYLENEOXAZOLINE TO A CHLORINATED INTERMEDIATE WHICH CAN BY HYROLYZED WITH AN AQUEOUS ACID TO PRODUCE MONOCHLOROKETONE FUNGICIDES ROHM AND HAAS COMPANY (US) 1999-08-10 US disclosed
US-5932738-A TRICHLOROISOCYANURIC ACID USED AS SELECTIVE CHLORINATION REAGENT IN THE CHLORINATION OF A 5-METHYLENEOXAZOLINE TO A CHLORINATED INTERMEDIATE WHICH CAN BY HYROLYZED WITH AN AQUEOUS ACID TO PRODUCE MONOCHLOROKETONE FUNGICIDES ROHM AND HAAS COMPANY (US) 1999-08-03 US disclosed
US-5925763-A MULTISTAGE PROCESS WITH CYCLIZATION OF AN ALKYNYL AMIDE TO FORM METHYLENEOXAZOLINE, CHLORINATION USING TRICHLOROISOCYANURIC ACID TO PRODUCE DICHLOROXAZOLINE INTERMEDIATES AND HYDROLYSIS ROHM AND HAAS COMPANY (US) 1999-07-20 US disclosed
US-5859254-A CYCLIZING ALKYNYLAMIDE USING AQUEOUS BASE IN PRESENCE OF ORGANIC SOLVENT AND PHASE TRANSFER AGENT, CHLORINATING PRODUCT IN SOLVENT WITH TRICHLOROISOCYANURIC ACID, HYDROLYZING CHLORINATED OXAZOLINE WITH AQUEOUS ACID ROHM AND HAAS COMPANY (US) 1999-01-12 US disclosed
EP-0879819-A1 Process for the preparation of 5-methylene oxazolines ROHM AND HAAS COMPANY (US) 1998-11-25 EP disclosed
EP-0872474-A2 Process for the preparation of chloroketones using oxazolines ROHM AND HAAS COMPANY (US) 1998-10-21 EP disclosed