Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.52 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 9/20 | 0.48 |
| ▸ | NPC1 | O15118 | 8/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 3/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11247340 | 1.00 | LMNA (0.52) | LMNANAPRTP4HTML3MBTL1ALDH1A1 | |
| SCHEMBL8024978 | 1.00 | LMNA (0.52) | LMNANAPRTP4HTML3MBTL1ALDH1A1 | |
| SCHEMBL11251009 | 0.85 | NPC1 (0.50) | ALDH1A1CES2CES1RAB9ANPC1 | |
| SCHEMBL11251013 | 0.85 | NPC1 (0.50) | ALDH1A1CES2CES1RAB9ANPC1 | |
| SCHEMBL11255658 | 0.83 | LMNA (0.47) | LMNANAPRTP4HTML3MBTL1ALDH1A1 | |
| SCHEMBL11255656 | 0.83 | LMNA (0.47) | LMNANAPRTP4HTML3MBTL1ALDH1A1 | |
| SCHEMBL3263278 | 0.79 | LMNA (0.59) | LMNANAPRTP4HTML3MBTL1ALDH1A1 | |
| SCHEMBL22559238 | 0.79 | LMNA (0.59) | LMNANAPRTP4HTML3MBTL1ALDH1A1 | |
| SCHEMBL3263280 | 0.79 | LMNA (0.59) | LMNANAPRTP4HTML3MBTL1ALDH1A1 | |
| SCHEMBL11249560 | 0.79 | NPC1 (0.44) | ALDH1A1RAB9ANPC1CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675133-B1 | 13-Substituted milbemycin derivatives, their preparation and use | SANKYO CO (JP) | 2000-01-12 | — | — | EP | disclosed |
| US-5614470-A | AGRICULTURAL ANTHELMINTIC, ACARICIDE, INSECTICIDE | SANKYO COMPANY, LIMITED (JP) | 1997-03-25 | — | — | US | disclosed |
| EP-0675133-A1 | 13-Substituted milbemycin derivatives, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1995-10-04 | — | — | EP | disclosed |
| US-4327213-A | ANTIULCER AGENTS | ACF Chemiefarma VA (NL) | 1982-04-27 | — | — | US | disclosed |