Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | GSR | P00390 | 1/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 7/20 | 0.33 |
| ▸ | DPP4 | P27487 | 3/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.33 |
| ▸ | FAP | Q12884 | 1/20 | 0.33 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL8025526 | 1.00 | ALDH1A1 (0.45) | ALDH1A1TSHRGSRDPP8DPP7 | |
| Aes-103 SCHEMBL8025663 | 0.88 | ALDH1A1 (0.50) | ALDH1A1TSHRTDP1 | |
| Aes-103 SCHEMBL8025669 | 0.88 | ALDH1A1 (0.50) | ALDH1A1TSHRTDP1 | |
| Lysine SCHEMBL8039060 | 0.87 | GSR (0.42) | ALDH1A1TSHRGSRDPP8DPP7 | |
| Lysine SCHEMBL8039058 | 0.87 | GSR (0.42) | ALDH1A1TSHRGSRDPP8DPP7 | |
| Lysine SCHEMBL8035753 | 0.83 | GRM8 (0.41) | ALDH1A1GSRPOLBKMT2ATDP1 | |
| Lysine SCHEMBL8035750 | 0.83 | GRM8 (0.41) | ALDH1A1GSRPOLBKMT2ATDP1 | |
| Aes-103 SCHEMBL8041166 | 0.82 | ALDH1A1 (0.56) | ALDH1A1TSHRPOLBTDP1 | |
| Aes-103 SCHEMBL7802522 | 0.82 | ALDH1A1 (0.67) | ALDH1A1TSHRPOLBTDP1 | |
| Lysine SCHEMBL8035898 | 0.81 | GSR (0.43) | ALDH1A1GSRDPP8DPP7DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |