Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PLG | P00747 | 1/20 | 0.33 |
| ▸ | PLAT | P00750 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclohexylamine SCHEMBL8039236 | 0.88 | ALDH1A1 (0.43) | ALDH1A1POLBTDP1L3MBTL1KMT2A | |
| Lysine SCHEMBL8039122 | 0.83 | GSR (0.48) | GSRDPP8DPP7DPP9POLB | |
| Lysine SCHEMBL8039060 | 0.82 | GSR (0.42) | GSRALDH1A1DPP8DPP7DPP9 | |
| Lysine SCHEMBL8039058 | 0.82 | GSR (0.42) | GSRALDH1A1DPP8DPP7DPP9 | |
| Cyclohexylamine SCHEMBL7800295 | 0.81 | ALDH1A1 (0.49) | ALDH1A1POLBTDP1L3MBTL1KMT2A | |
| Lysine SCHEMBL8025526 | 0.81 | ALDH1A1 (0.45) | GSRALDH1A1DPP8DPP7DPP9 | |
| Lysine SCHEMBL8025523 | 0.81 | ALDH1A1 (0.45) | GSRALDH1A1DPP8DPP7DPP9 | |
| Lysine SCHEMBL8039218 | 0.81 | GSR (0.43) | GSRDPP8DPP7DPP9POLB | |
| Lysine SCHEMBL8025623 | 0.81 | GSR (0.44) | GSRALDH1A1DPP8DPP7DPP9 | |
| Lysine SCHEMBL8025620 | 0.81 | GSR (0.44) | GSRALDH1A1DPP8DPP7DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |