Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of 2-Naphthaldehyde. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.43 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.43 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.43 |
| ▸ | GSR | P00390 | 1/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | MC4R | P32245 | 2/20 | 0.37 |
| ▸ | MC5R | P33032 | 2/20 | 0.37 |
| ▸ | MC3R | P41968 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 2/20 | 0.37 |
| ▸ | PPARA | Q07869 | 2/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 2/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Naphthaldehyde SCHEMBL8025531 | 1.00 | GRIK1 (0.43) | GRIK1GRIK2GRIK3GSRDPP8 | |
| Lysine SCHEMBL8039122 | 0.89 | GSR (0.48) | GSRDPP8DPP7DPP9CPB2 | |
| 2-Naphthaldehyde SCHEMBL8035927 | 0.88 | GRIK1 (0.46) | GRIK1GRIK2GRIK3PPARGPPARA | |
| 2-Naphthaldehyde SCHEMBL8035922 | 0.88 | GRIK1 (0.46) | GRIK1GRIK2GRIK3PPARGPPARA | |
| Lysine SCHEMBL7798348 | 0.87 | GSR (0.43) | GRIK1GRIK2GSRDPP8DPP7 | |
| Lysine SCHEMBL7800895 | 0.87 | GSR (0.43) | GRIK1GRIK2GSRDPP8DPP7 | |
| Lysine SCHEMBL7792734 | 0.87 | GSR (0.43) | GRIK1GRIK2GSRDPP8DPP7 | |
| Lysine SCHEMBL7792738 | 0.87 | GSR (0.43) | GRIK1GRIK2GSRDPP8DPP7 | |
| Lysine SCHEMBL8035239 | 0.87 | DPP8 (0.45) | GSRDPP8DPP7DPP9PPARG | |
| Lysine SCHEMBL8035235 | 0.87 | DPP8 (0.45) | GSRDPP8DPP7DPP9PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |