Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.45 |
| ▸ | LTA4H | P09960 | 3/20 | 0.42 |
| ▸ | GSR | P00390 | 1/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL8035235 | 1.00 | DPP8 (0.45) | DPP8LTA4HGSRDPP7NPY5R | |
| Lysine SCHEMBL8025565 | 0.92 | DPP8 (0.43) | DPP8LTA4HGSRDPP7 | |
| Lysine SCHEMBL8025564 | 0.92 | DPP8 (0.43) | DPP8LTA4HGSRDPP7 | |
| Lysine SCHEMBL8039122 | 0.90 | GSR (0.48) | DPP8GSRDPP7MMP2DPP9 | |
| Lysine SCHEMBL7792738 | 0.89 | GSR (0.43) | DPP8GSRDPP7MMP2MMP9 | |
| Lysine SCHEMBL7800895 | 0.89 | GSR (0.43) | DPP8GSRDPP7MMP2MMP9 | |
| Lysine SCHEMBL7798348 | 0.89 | GSR (0.43) | DPP8GSRDPP7MMP2MMP9 | |
| Lysine SCHEMBL7792734 | 0.89 | GSR (0.43) | DPP8GSRDPP7MMP2MMP9 | |
| Cyclohexylamine SCHEMBL8041275 | 0.88 | LTA4H (0.40) | LTA4HNPY5RPARP10PARP3PPARG | |
| Cyclohexylamine SCHEMBL8041272 | 0.88 | LTA4H (0.40) | LTA4HNPY5RPARP10PARP3PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |