Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.50 |
| ▸ | AGXT | P21549 | 2/20 | 0.50 |
| ▸ | CMA1 | P23946 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TACR1 | P25103 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 4/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | NAAA | Q02083 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | EED | O75530 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18616424 | 0.85 | ALDH1A1 (0.61) | IDO1AGXTALDH1A1TACR1MAOB | |
| SCHEMBL23072237 | 0.84 | ALDH1A1 (0.60) | IDO1AGXTALDH1A1TACR1MAOB | |
| SCHEMBL5521345 | 0.79 | CARM1 (0.54) | IDO1AGXTTACR1MAOBSIGMAR1 | |
| SCHEMBL8022023 | 0.78 | HSP90AA1 (0.47) | IDO1AGXTCMA1ALDH1A1TACR1 | |
| SCHEMBL416422 | 0.78 | OPRM1 (0.50) | SIGMAR1 | |
| SCHEMBL22412744 | 0.78 | SLC6A4 (0.58) | IDO1AGXTALDH1A1MAOBTAAR1 | |
| SCHEMBL8009617 | 0.77 | SLC6A2 (0.56) | ALDH1A1NPC1RAB9A | |
| SCHEMBL8633784 | 0.76 | CARM1 (0.57) | IDO1TACR1MAOBMMP1MMP12 | |
| SCHEMBL12012201 | 0.76 | SLC6A4 (0.63) | IDO1AGXTALDH1A1TACR1MAOB | |
| Ethylene SCHEMBL7936439 | 0.75 | OPRM1 (0.48) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780369-B1 | 1-Phenyl-2-dimethylaminomethyl-cyclohexan-1-ol derivatives as pharmaceutical agents | GRUENENTHAL GMBH (DE) | 2000-01-19 | — | — | EP | disclosed |
| US-5801201-A | 1-phenyl-2-dimenthylaminomethyl-cyclohexan-1-ol compounds as pharmaceutical active ingredients | GRUENENTHAL GMBH (DE) | 1998-09-01 | — | — | US | disclosed |
| EP-0780369-A1 | 1-Phenyl-2-dimethylaminomethyl-cyclohexan-1-ol derivatives as pharmaceutical agents | Grünenthal GmbH (DE) | 1997-06-25 | — | — | EP | disclosed |