Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Cyclohexylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.37 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.36 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.36 |
| ▸ | CYBB | P04839 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclohexylamine SCHEMBL7798634 | 0.89 | CYP2A6 (0.63) | CYP2A6CYP2A13EPHX1HSD17B3MEN1 | |
| Cyclohexylamine SCHEMBL8041396 | 0.87 | CYP2A6 (0.44) | CYP2A6CYP2A13EPHX1HSD17B3MEN1 | |
| Cyclohexylamine SCHEMBL8041402 | 0.87 | CYP2A6 (0.44) | CYP2A6CYP2A13EPHX1HSD17B3MEN1 | |
| Glycine SCHEMBL8218299 | 0.86 | CYP2A6 (0.68) | CYP2A6CYP2A13HSD17B3MAPTKMT2A | |
| 4-Hydroxybenzaldehyde SCHEMBL7798048 | 0.83 | ALDH5A1 (0.47) | EPHX1MEN1KMT2AALDH1A1TRPM8 | |
| Benzaldehyde SCHEMBL7798223 | 0.83 | ALDH1A1 (0.44) | CYP2A6MEN1KMT2AALDH1A1TRPM8 | |
| Cyclohexylamine SCHEMBL7801490 | 0.82 | ALDH1A1 (0.54) | EPHX1MEN1MAPTKMT2AALDH1A1 | |
| Cyclohexylamine SCHEMBL7792125 | 0.82 | CACNA1B (0.41) | MAPTKMT2AALDH1A1 | |
| Cyclohexylamine SCHEMBL7802678 | 0.82 | CYP1A2 (0.42) | EPHX1MEN1KMT2AHDAC3HDAC1 | |
| Lysine SCHEMBL8039163 | 0.82 | GSR (0.42) | CYP2A6CYP2A13EPHX1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |