Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 9/20 | 0.76 |
| ▸ | LTA4H | P09960 | 6/20 | 0.71 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | F2 | P00734 | 1/20 | 0.56 |
| ▸ | REN | P00797 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | PEPD | P12955 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.56 |
| ▸ | HRH1 | P35367 | 1/20 | 0.56 |
| ▸ | THPO | P40225 | 1/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7381708 | 1.00 | ACE (0.76) | ACELTA4HACE2KDM4EF2 | |
| SCHEMBL9554734 | 0.93 | ACE (0.81) | ACELTA4HACE2 | |
| SCHEMBL9554742 | 0.93 | ACE (0.81) | ACELTA4HACE2 | |
| SCHEMBL7377893 | 0.90 | ACE (0.73) | ACELTA4HACE2 | |
| SCHEMBL6787617 | 0.90 | ACE (0.76) | ACELTA4HACE2 | |
| SCHEMBL6787624 | 0.90 | ACE (0.76) | ACELTA4HACE2 | |
| SCHEMBL11563629 | 0.87 | LTA4H (0.78) | ACELTA4HACE2REN | |
| SCHEMBL7315965 | 0.85 | ACE (0.63) | ACELTA4HACE2 | |
| SCHEMBL11560122 | 0.85 | LTA4H (0.71) | ACELTA4HACE2REN | |
| SCHEMBL11558098 | 0.85 | LTA4H (0.75) | ACELTA4HACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6022885-A | Pyrrolidine and thiazole derivatives with antibacterial and . metallo-.beta-lactamase inhibitory properties | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-02-08 | — | — | US | claimed |