Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPN | P05981 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30782027 | 0.81 | SCN2A (0.57) | HPNLMNATSHRKEAP1NFE2L2 | |
| SCHEMBL2627226 | 0.81 | SCN2A (0.57) | HPNLMNATSHRKEAP1NFE2L2 | |
| SCHEMBL1186577 | 0.80 | KMT2A (0.50) | MAPTMEN1KMT2ASCN2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL10799631 | 0.78 | KMT2A (0.49) | MAPTMEN1KMT2ASCN2ASMN1; SMN2 | |
| SCHEMBL8230259 | 0.74 | NOTUM (0.51) | LMNAMAPTMEN1KMT2AKDM4E | |
| SCHEMBL21876439 | 0.74 | MAPT (0.49) | HPNLMNATSHRMAPTMEN1 | |
| SCHEMBL20502000 | 0.74 | SMN1; SMN2 (0.52) | HPNLMNATSHRKEAP1NFE2L2 | |
| SCHEMBL2627225 | 0.73 | NOTUM (0.59) | HPNLMNATSHRKEAP1NFE2L2 | |
| SCHEMBL4456339 | 0.73 | KEAP1 (0.51) | HPNLMNATSHRKEAP1NFE2L2 | |
| SCHEMBL3164608 | 0.73 | KMT2A (0.55) | HPNLMNATSHRKEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6037345-A | Method for inhibiting neoplastic cells and related conditions by exposure to quinazolinedione and pyridopyrimidinedione derivatives | CELL PATHWAYS, INC. (US) | 2000-03-14 | — | — | US | disclosed |
| EP-0260817-B1 | QUINAZOLINEDIONES AND PYRIDOPYRIMIDINEDIONES | PFIZER INC. (US) | 1991-05-15 | — | — | EP | disclosed |
| US-4880810-A | Quinazolinediones and pyridopyrimidinediones | PFIZER INC. (US) | 1989-11-14 | — | — | US | disclosed |
| US-4797403-A | Quinazolinediones and pyridopyrimidinediones | PFIZER INC. (US) | 1989-01-10 | — | — | US | disclosed |
| EP-0260817-A1 | Quinazolinediones and pyridopyrimidinediones | PFIZER INC. (US) | 1988-03-23 | — | — | EP | disclosed |