Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.67 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.54 |
| ▸ | GRM1 | Q13255 | 10/20 | 0.54 |
| ▸ | GRM5 | P41594 | 9/20 | 0.54 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | IDE | P14735 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14540703 | 0.84 | HTR6 (0.70) | HTR6PDK4GRM1GRM5SCN9A | |
| SCHEMBL8026745 | 0.81 | HTR6 (0.66) | HTR6PDK4GRM1GRM5SCN9A | |
| SCHEMBL16259062 | 0.77 | HTR6 (0.63) | HTR6PDK4GRM1GRM5SCN9A | |
| SCHEMBL14406149 | 0.77 | HTR6 (0.63) | HTR6PDK4GRM1GRM5SCN9A | |
| SCHEMBL2239831 | 0.77 | NAMPT (0.66) | HTR6PDK4GRM1GRM5NAMPT | |
| SCHEMBL6847847 | 0.76 | PDK4 (0.69) | HTR6PDK4GRM1GRM5SCN9A | |
| SCHEMBL19297042 | 0.76 | PDK4 (0.62) | HTR6PDK4GRM1GRM5NAMPT | |
| SCHEMBL19284673 | 0.76 | PDK4 (0.62) | HTR6PDK4GRM1GRM5NAMPT | |
| SCHEMBL17268510 | 0.76 | PDK4 (0.68) | HTR6PDK4GRM1GRM5NAMPT | |
| SCHEMBL14333803 | 0.76 | HTR6 (0.61) | HTR6PDK4GRM1GRM5SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000037074-A1 | MUTILIN 14-ESTER DERIVATIVES HAVING ANTIBACTERIAL ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 2000-06-29 | — | — | WO | disclosed |