Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HPD | P32754 | 6/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.45 |
| ▸ | CCND1 | P24385 | 1/20 | 0.45 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL860576 | 1.00 | MEN1 (0.47) | MEN1KMT2APOLBHPDCCNB2 | |
| SCHEMBL5319025 | 0.86 | KMT2A (0.44) | MEN1KMT2APOLBHPDMAPT | |
| SCHEMBL877419 | 0.82 | MAPT (0.40) | MEN1KMT2AMAPTNPC1LMNA | |
| SCHEMBL6191797 | 0.81 | POLB (0.55) | MEN1KMT2APOLBMAPTNPC1 | |
| SCHEMBL6191804 | 0.81 | POLB (0.55) | MEN1KMT2APOLBMAPTNPC1 | |
| SCHEMBL8009754 | 0.81 | POLB (0.55) | MEN1KMT2APOLBMAPTNPC1 | |
| SCHEMBL8009758 | 0.81 | POLB (0.55) | MEN1KMT2APOLBMAPTNPC1 | |
| SCHEMBL8026956 | 0.81 | POLB (0.49) | MEN1KMT2APOLBMAPTNPC1 | |
| SCHEMBL23748560 | 0.81 | CCNB2 (0.52) | MEN1KMT2APOLBHPDCCNB2 | |
| SCHEMBL3611368 | 0.81 | POLB (0.49) | MEN1KMT2APOLBHPDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000064917-A2 | SYNTHETIC INDOLOCARBAZOLE REGIOISOMERS AND USES THEREOF | ADVANCED LIFE SCIENCES INC. (US) | 2000-11-02 | — | — | WO | disclosed |
| US-4810699-A | Substituted 1,3,4,9-tetrahydropyrano[3,4,-b]indole-1-acetic acids, pharmaceutical compositions containing them, and methods for treating inflammatory conditions and for analgesic purposes using them | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-03-07 | — | — | US | disclosed |