Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 17/20 | 1.00 |
| ▸ | DRD2 | P14416 | 11/20 | 1.00 |
| ▸ | CCNC | P24863 | 2/20 | 0.49 |
| ▸ | CDK8 | P49336 | 2/20 | 0.49 |
| ▸ | CDK19 | Q9BWU1 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8022012 | 0.98 | DRD4 (0.97) | DRD4DRD2CCNCCDK8CDK19 | |
| SCHEMBL8022043 | 0.91 | DRD4 (1.00) | DRD4DRD2CCNCCDK8CDK19 | |
| Hydrochloric Acid SCHEMBL8011148 | 0.89 | DRD4 (0.97) | DRD4DRD2CCNCCDK8CDK19 | |
| SCHEMBL7246869 | 0.82 | DRD4 (0.68) | DRD4DRD2CCNCCDK8CDK19 | |
| SCHEMBL7241539 | 0.81 | CCNC (0.72) | DRD4DRD2CCNCCDK8CDK19 | |
| SCHEMBL7241940 | 0.77 | DRD2 (0.61) | DRD4DRD2CCNCCDK8CDK19 | |
| SCHEMBL9212631 | 0.71 | DRD4 (0.55) | DRD4DRD2CCNCCDK8CDK19 | |
| SCHEMBL7248682 | 0.69 | DRD4 (0.52) | DRD4DRD2CCNCCDK8CDK19 | |
| SCHEMBL9222650 | 0.69 | DRD2 (0.53) | DRD4DRD2CCNCCDK8CDK19 | |
| SCHEMBL7246960 | 0.69 | CCNC (0.52) | DRD4DRD2CCNCCDK8CDK19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6034252-A | Substituted thienocycloalkylpyrazoles: dopamine receptor subtype specific ligands | NEUROGEN CORPORATION (US) | 2000-03-07 | — | — | US | claimed |