Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 10/20 | 0.52 |
| ▸ | MME | P08473 | 11/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.41 |
| ▸ | GPR34 | Q9UPC5 | 2/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27462305 | 0.95 | ACE (0.47) | ACEMMEPPARGPPARAKLKB1 | |
| SCHEMBL8027312 | 0.92 | ACE (0.61) | ACEMMEPPARGPPARAMEN1 | |
| SCHEMBL8030383 | 0.91 | MME (0.64) | ACEMMEPPARGPPARAMEN1 | |
| SCHEMBL27463258 | 0.91 | MME (0.64) | ACEMMEPPARGPPARAMEN1 | |
| SCHEMBL8027428 | 0.90 | ACE (0.47) | ACEMMEPPARGPPARAMEN1 | |
| SCHEMBL8017382 | 0.89 | MME (0.63) | ACEMMEGPR34 | |
| SCHEMBL8017386 | 0.89 | MME (0.63) | ACEMMEGPR34 | |
| SCHEMBL8017737 | 0.87 | ACE (0.64) | ACEMMEMEN1KMT2A | |
| SCHEMBL8027402 | 0.87 | ACE (0.48) | ACEMMEPPARGPPARAMEN1 | |
| SCHEMBL27441332 | 0.87 | MME (0.57) | ACEMMEPPARGPPARAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0738711-B1 | NOVEL 1,3-DIALKYLUREA DERIVATIVE HAVING HYDROXYL GROUP | SANTEN PHARMACEUTICAL CO LTD (JP) | 2000-03-08 | — | — | EP | disclosed |
| EP-0738711-A1 | NOVEL 1,3-DIALKYLUREA DERIVATIVE HAVING HYDROXYL GROUP | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1996-10-23 | — | — | EP | disclosed |