Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 3/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL252505 | 0.76 | ACHE (0.55) | ACHEALDH1A1ABCB1PIK3CDHPGD | |
| SCHEMBL10938522 | 0.74 | ACHE (0.53) | ACHEALDH1A1ABCB1PIK3CDHPGD | |
| SCHEMBL1690525 | 0.73 | LMNA (0.54) | ACHEALDH1A1ABCB1GAASMN1; SMN2 | |
| SCHEMBL18970120 | 0.73 | LMNA (0.54) | ACHEALDH1A1ABCB1GAASMN1; SMN2 | |
| SCHEMBL19454030 | 0.71 | HPGD (0.64) | ACHEHPGDGAATSHRRECQL | |
| SCHEMBL19453836 | 0.71 | PIK3CD (0.50) | ACHEALDH1A1ABCB1PIK3CDHPGD | |
| SCHEMBL18435999 | 0.70 | ACHE (0.49) | ACHEALDH1A1PIK3CDHPGDSMN1; SMN2 | |
| SCHEMBL11605536 | 0.70 | ACHE (0.49) | ACHEALDH1A1ABCB1PIK3CDHPGD | |
| SCHEMBL18080914 | 0.70 | SMO (0.53) | ACHEHPGDGAATSHRRECQL | |
| SCHEMBL23018151 | 0.70 | KMT2A (0.42) | ALDH1A1BRD4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6121325-A | Naphthyl compounds promote release of growth hormone | MERCK & CO., INC. (US) | 2000-09-19 | — | — | US | disclosed |
| EP-0730578-A4 | INDOLYL GROUP CONTAINING COMPOUNDS AND THE USE THEREOF TO PROMOTE THE RELEASE OF GROWTH HORMONE(S) | MERCK & CO INC (US) | 1997-10-08 | — | — | EP | disclosed |
| US-5663171-A | FOR USE IN HUMANS OR ANIMALS | MERCK & CO., INC. (US) | 1997-09-02 | — | — | US | disclosed |
| EP-0730578-A1 | INDOLYL GROUP CONTAINING COMPOUNDS AND THE USE THEREOF TO PROMOTE THE RELEASE OF GROWTH HORMONE(S) | MERCK & CO. INC. (US) | 1996-09-11 | — | — | EP | disclosed |
| WO-1995014666-A1 | INDOLYL GROUP CONTAINING COMPOUNDS AND THE USE THEREOF TO PROMOTE THE RELEASE OF GROWTH HORMONE(S) | MERCK & CO., INC. (US) | 1995-06-01 | — | — | WO | disclosed |