Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.56 |
| ▸ | HTR2C | P28335 | 6/20 | 0.49 |
| ▸ | HTR2B | P41595 | 6/20 | 0.49 |
| ▸ | HTR2A | P28223 | 6/20 | 0.49 |
| ▸ | HTR1A | P08908 | 5/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 5/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8023881 | 0.81 | MAOA (0.57) | MAOAHTR2CHTR2BHTR1ASLC6A4 | |
| SCHEMBL7655001 | 0.79 | MAOA (0.56) | MAOAHTR2AHTR1AADRA2CASIC3 | |
| SCHEMBL8029002 | 0.79 | MAOA (0.56) | MAOAHTR2CHTR2ASLC6A4ASIC3 | |
| SCHEMBL8012740 | 0.79 | MAOA (0.56) | MAOAHTR2CHTR2ASLC6A4ASIC3 | |
| SCHEMBL8024193 | 0.79 | MAOA (0.56) | MAOAHTR2CHTR2BHTR2AADRA2A | |
| SCHEMBL29557733 | 0.79 | MAOA (0.56) | MAOAHTR2AHTR1AADRA2CASIC3 | |
| SCHEMBL8032028 | 0.79 | MAOA (0.64) | MAOAHTR2CHTR2BHTR2ADRD2 | |
| Hydrochloric Acid SCHEMBL7513323 | 0.78 | MAOA (0.54) | MAOAHTR2AHTR1AADRA2CASIC3 | |
| SCHEMBL1095493 | 0.77 | DRD3 (0.54) | HTR2CHTR2BHTR2AHTR1ASLC6A4 | |
| SCHEMBL1095494 | 0.77 | DRD3 (0.54) | HTR2CHTR2BHTR2AHTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |