Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
| ▸ | HTR2B | P41595 | 2/20 | 0.49 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | PRCP | P42785 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | PNMT | P11086 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8011243 | 0.86 | MAOA (0.56) | MAOAHTR2AHTR2CHTR2BPLAU | |
| SCHEMBL18100258 | 0.82 | OPRM1 (0.45) | MAOAHTR2AHTR2CHTR2BOPRM1 | |
| SCHEMBL8023881 | 0.81 | MAOA (0.57) | MAOAHTR2CHTR2BPLAUOPRM1 | |
| SCHEMBL29557733 | 0.79 | MAOA (0.56) | MAOAHTR2APLAUASIC3DRD2 | |
| SCHEMBL7655001 | 0.79 | MAOA (0.56) | MAOAHTR2APLAUASIC3DRD2 | |
| SCHEMBL8012740 | 0.79 | MAOA (0.56) | MAOAHTR2AHTR2CPLAUASIC3 | |
| SCHEMBL8028684 | 0.79 | MAOA (0.56) | MAOAHTR2AHTR2CHTR2BPLAU | |
| SCHEMBL8029002 | 0.79 | MAOA (0.56) | MAOAHTR2AHTR2CPLAUASIC3 | |
| SCHEMBL31536303 | 0.79 | ASIC3 (0.48) | HTR2AHTR2CHTR2BPLAUOPRM1 | |
| SCHEMBL8032032 | 0.79 | MAOA (0.64) | MAOAHTR2AHTR2CPLAUDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |