Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 5/20 | 0.33 |
| ▸ | RAB9A | P51151 | 5/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL558663 | 0.79 | — | — | |
| SCHEMBL6003977 | 0.74 | RECQL (0.58) | RECQLNOTUMACE2 | |
| SCHEMBL981283 | 0.65 | ACHE (1.00) | ACHELMNATHRBTP53MAPT | |
| SCHEMBL29164847 | 0.64 | ACHE (0.42) | ACHELMNATP53MAPTBCHE | |
| SCHEMBL30822733 | 0.64 | ACHE (0.42) | ACHELMNATP53MAPTBCHE | |
| SCHEMBL16597159 | 0.64 | ACHE (0.50) | ACHEBCHE | |
| SCHEMBL2618901 | 0.64 | LMNA (0.66) | ACHELMNATHRBTP53MAPT | |
| SCHEMBL21547867 | 0.64 | PPARA (0.49) | ACHELMNATHRBTP53NPC1 | |
| SCHEMBL13415305 | 0.64 | ACHE (0.80) | ACHELMNATHRBTP53MAPT | |
| SCHEMBL2618848 | 0.63 | LMNA (0.69) | ACHELMNATHRBTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663171-A | FOR USE IN HUMANS OR ANIMALS | MERCK & CO., INC. (US) | 1997-09-02 | — | — | US | claimed |
| US-6121325-A | Naphthyl compounds promote release of growth hormone | MERCK & CO., INC. (US) | 2000-09-19 | — | — | US | disclosed |
| US-5663171-A | FOR USE IN HUMANS OR ANIMALS | MERCK & CO., INC. (US) | 1997-09-02 | — | — | US | disclosed |