SCHEMBL8029160

SCHEMBL8029160

CCc1nc2c(C)cc(C)nc2n1Cc1ccc2nc(-c3ccccc3N)ccc2c1

nearest known ligand 0.56

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
GPR4 P46093 2/20 0.52
AGTR1 P30556 2/20 0.51
AGTR2 P50052 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7376048 0.85
SCHEMBL8384340 0.85 AGTR1 (0.55) AGTR1AGTR2
SCHEMBL6558915 0.85
SCHEMBL6558909 0.84
SCHEMBL8914997 0.83 AGTR1 (0.53) GPR4AGTR1AGTR2
SCHEMBL8913338 0.83
SCHEMBL5434268 0.83 AGTR1 (0.68) AGTR1AGTR2
Ga0113 SCHEMBL7763027 0.82 AGTR1 (0.49) AGTR1AGTR2
Ga0113 SCHEMBL8803985 0.81 AGTR1 (0.48) AGTR1AGTR2
SCHEMBL5780517 0.81 AGTR1 (0.55) GPR4AGTR1AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5856337-A 2-arylquinolines and process for producing the same ASAHI GLASS CO., LTD. (JP) 1999-01-05 US claimed
EP-0786460-A2 2-Arylquinolines and process for producing the same ASAHI GLASS COMPANY LTD. (JP) 1997-07-30 EP claimed
US-6060480-A Preventives/remedies for muscle tissue degenerations YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 2000-05-09 US disclosed
EP-0920866-A1 PREVENTIVES/REMEDIES FOR MUSCLE TISSUE DEGENERATIONS YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1999-06-09 EP disclosed
US-5856337-A 2-arylquinolines and process for producing the same ASAHI GLASS CO., LTD. (JP) 1999-01-05 US disclosed
CN-1171397-A Crystal of N-[(quinolin-2-yl) phenyl] sulfonamides and process for producing same ASAHI GLASS CO LTD (JP) 1998-01-28 CN disclosed
EP-0812841-A1 Crystal of N-((quinolin-2-yl)-phenyl)sulfonamides and process for producing the same ASAHI GLASS COMPANY LTD. (JP) 1997-12-17 EP disclosed
EP-0786460-A2 2-Arylquinolines and process for producing the same ASAHI GLASS COMPANY LTD. (JP) 1997-07-30 EP disclosed