SCHEMBL8029455

SCHEMBL8029455

COc1ccc(-c2ccc(C=O)cc2)nc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.58
CYP2A6 P11509 1/20 0.58
RXFP1 Q9HBX9 1/20 0.53
CASP3 P42574 2/20 0.46
SENP7 Q9BQF6 2/20 0.46
SENP8 Q96LD8 1/20 0.46
SENP6 Q9GZR1 1/20 0.46
NPC1 O15118 4/20 0.45
RAB9A P51151 4/20 0.45
CYP11B1 P15538 2/20 0.45
PTGER4 P35408 1/20 0.44
LMNA P02545 2/20 0.41
KDM4E B2RXH2 3/20 0.41
MAPT P10636 1/20 0.41
DRD1 P21728 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
ALDH1A3 P47895 1/20 0.41
BRAF P15056 1/20 0.40
MEN1 O00255 1/20 0.40
USP2 O75604 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28620480 0.90 ALDH1A1 (0.59) ALDH1A1CYP2A6RXFP1CASP3SENP7
SCHEMBL9607472 0.90 ALDH1A1 (0.58) ALDH1A1CYP2A6RXFP1CASP3SENP7
SCHEMBL15258007 0.86 ALDH1A1 (0.57) ALDH1A1CYP2A6RXFP1NPC1RAB9A
SCHEMBL21034959 0.81 CYP11B1 (0.43) ALDH1A1CYP2A6RXFP1NPC1RAB9A
SCHEMBL28682644 0.80 CYP11B1 (0.56) ALDH1A1CYP2A6RXFP1CASP3SENP7
SCHEMBL30747787 0.80 CYP11B1 (0.56) ALDH1A1CYP2A6RXFP1CASP3SENP7
Formic Acid Methyl Ester SCHEMBL27958604 0.80 RXFP1 (0.49) ALDH1A1RXFP1CASP3SENP7SENP8
SCHEMBL17754087 0.79 RXFP1 (0.54) RXFP1CASP3SENP7SENP8SENP6
SCHEMBL6351 0.78 ALDH1A1 (0.86) ALDH1A1CYP2A6LMNAKDM4EMAPT
SCHEMBL19214399 0.78 ALDH1A1 (0.86) ALDH1A1CYP2A6LMNAKDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111154115-B Preparation method and application of binuclear Ir (III) metal-organic supermolecular cage-like compound 大连理工大学 2021-09-21 CN claimed
CN-111154115-A Preparation method and application of binuclear Ir (III) metal-organic supermolecular cage-like compound 大连理工大学 2020-05-15 CN claimed
CN-111154115-B Preparation method and application of binuclear Ir (III) metal-organic supermolecular cage-like compound 大连理工大学 2021-09-21 CN disclosed
CN-111154115-A Preparation method and application of binuclear Ir (III) metal-organic supermolecular cage-like compound 大连理工大学 2020-05-15 CN disclosed
US-9422240-B2 Partially saturated nitrogen-containing heterocyclic compound TAISHO PHARMACEUTICAL CO., LTD (JP) 2016-08-23 US disclosed
US-9422240-B2 Partially saturated nitrogen-containing heterocyclic compound TAISHO PHARMACEUTICAL CO., LTD (JP) 2016-08-23 US disclosed
US-20150175541-A1 PARTIALLY SATURATED NITROGEN-CONTAINING HETEROCYCLIC COMPOUND TAISHO PHARMACEUTICAL CO., LTD (JP) 2015-06-25 US disclosed
US-20150175541-A1 PARTIALLY SATURATED NITROGEN-CONTAINING HETEROCYCLIC COMPOUND TAISHO PHARMACEUTICAL CO., LTD (JP) 2015-06-25 US disclosed
WO-2009071504-A1 2,6-DISUBSTITUTED PYRIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS SMITHKLINE BEECHAM CORPORATION (US) 2009-06-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150175541-A1 PARTIALLY SATURATED NITROGEN-CONTAINING HETEROCYCLIC COMPOUND EGLN2, EGLN3, EGLN1 ALDH1A1 2293/4885CYP2A6 582/4885RXFP1 1163/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.