Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.48 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.63 |
| ▸ | DHODH | Q02127 | 5/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | GLA | P06280 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CDC7 | O00311 | 1/20 | 0.49 |
| ▸ | EEF2K | O00418 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL8029606 | 1.00 | PDE10A (0.63) | PDE10ADHODHLMNAALDH1A1KDM4E | |
| SCHEMBL29377848 | 0.98 | PDE10A (0.66) | PDE10ADHODHLMNAALDH1A1KDM4E | |
| SCHEMBL641899 | 0.98 | PDE10A (0.66) | PDE10ADHODHLMNAALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL1603404 | 0.95 | PDE10A (0.63) | PDE10ADHODHLMNAALDH1A1KDM4E | |
| Water SCHEMBL2991911 | 0.95 | PDE10A (0.63) | PDE10ADHODHLMNAALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL9597551 | 0.95 | PDE10A (0.63) | PDE10ADHODHLMNAALDH1A1KDM4E | |
| SCHEMBL7516228 | 0.88 | PDE10A (0.56) | PDE10ADHODHLMNAALDH1A1KDM4E | |
| SCHEMBL9056825 | 0.86 | PDE10A (0.54) | PDE10ADHODHLMNAALDH1A1KDM4E | |
| SCHEMBL9056820 | 0.86 | PDE10A (0.54) | PDE10ADHODHLMNAALDH1A1KDM4E | |
| SCHEMBL9330222 | 0.85 | CYP2C19 (0.58) | PDE10ADHODHLMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0988551-A2 | CHEMILUMINESCENT ENERGY TRANSFER CONJUGATES AND THEIR USES AS LABELS IN BINDING ASSAYS | Bayer Corporation (US) | 2000-03-29 | — | — | EP | disclosed |
| WO-1998054574-A2 | CHEMILUMINESCENT ENERGY TRANSFER CONJUGATES AND THEIR USES AS LABELS IN BINDING ASSAYS | BAYER CORPORATION (US) | 1998-12-03 | — | — | WO | disclosed |