Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.45 |
| ▸ | ACSL1 | P33121 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | JAK1 | P23458 | 2/20 | 0.44 |
| ▸ | TYK2 | P29597 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | F2 | P00734 | 6/20 | 0.43 |
| ▸ | ITK | Q08881 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 3/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8026843 | 0.83 | F2 (0.58) | F2 | |
| SCHEMBL8017278 | 0.81 | ITK (0.51) | ACSL1ITKCNR2CNR1 | |
| SCHEMBL8032027 | 0.81 | ACSL1 (0.43) | RORCACSL1JAK2JAK1TYK2 | |
| SCHEMBL8015782 | 0.80 | RORC (0.58) | RORCHDAC6HDAC1 | |
| SCHEMBL8029874 | 0.80 | ACSL1 (0.43) | RORCACSL1JAK2JAK1TYK2 | |
| SCHEMBL8028137 | 0.78 | CNR2 (0.48) | RORCACSL1F2CNR2IDH1 | |
| SCHEMBL6486632 | 0.78 | F2 (0.50) | ACSL1JAK2JAK1TYK2JAK3 | |
| Hydrochloric Acid SCHEMBL7244675 | 0.77 | F2 (0.49) | ACSL1JAK2JAK1TYK2JAK3 | |
| SCHEMBL7244672 | 0.77 | F2 (0.47) | RORCJAK2JAK1TYK2JAK3 | |
| SCHEMBL8028885 | 0.77 | HDAC6 (0.46) | ACSL1F2HDAC6HDAC1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1060166-A1 | FIVE-MEMBERED, BENZO-CONDENSED HETEROCYCLES USED AS ANTITHROMBOTIC AGENTS | Boehringer Ingelheim Pharma KG (DE) | 2000-12-20 | — | — | EP | disclosed |
| US-6114532-A | ANTICOAGULANT | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-09-05 | — | — | US | disclosed |
| WO-1999040072-A1 | FIVE-MEMBERED, BENZO-CONDENSED HETEROCYCLES USED AS ANTITHROMBOTIC AGENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-08-12 | — | — | WO | disclosed |