Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.54 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | GLA | P06280 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 2/20 | 0.36 |
| ▸ | CASP7 | P55210 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8024325 | 0.72 | MAOA (0.43) | MAOAPLAUPRCP | |
| SCHEMBL15161703 | 0.72 | MAOA (0.66) | MAOAPLAUALDH1A1KDM4EGLA | |
| SCHEMBL8031039 | 0.71 | MAOA (0.49) | MAOAALDH1A1KDM4EHSD17B10CYP2D6 | |
| SCHEMBL1013037 | 0.71 | MAOA (0.53) | MAOASLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL25384852 | 0.70 | MAOA (1.00) | MAOAKDM4EHSD17B10TSHRDRD1 | |
| SCHEMBL8032032 | 0.70 | MAOA (0.64) | MAOAPLAUSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8034457 | 0.70 | MAOA (0.64) | MAOAPLAUALDH1A1KDM4EGLA | |
| SCHEMBL10029583 | 0.70 | MAOA (1.00) | MAOAKDM4EHSD17B10TSHRDRD1 | |
| SCHEMBL8032028 | 0.70 | MAOA (0.64) | MAOAALDH1A1KDM4EGLAHPGD | |
| SCHEMBL8278403 | 0.70 | MAOA (1.00) | MAOAKDM4EHSD17B10TSHRDRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |