Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.64 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | GLA | P06280 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 2/20 | 0.38 |
| ▸ | CASP7 | P55210 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KCNN2 | Q9H2S1 | 4/20 | 0.36 |
| ▸ | KCNN3 | Q9UGI6 | 4/20 | 0.36 |
| ▸ | KCNN1 | Q92952 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15161703 | 0.79 | MAOA (0.66) | MAOAASIC3KDM4EALDH1A1HSD17B10 | |
| SCHEMBL8032013 | 0.79 | MAOA (0.56) | MAOAHTR2AHTR2CDRD2 | |
| SCHEMBL8012740 | 0.79 | MAOA (0.56) | MAOAASIC3PLAUHTR2AHTR2C | |
| SCHEMBL8029002 | 0.79 | MAOA (0.56) | MAOAASIC3PLAUHTR2AHTR2C | |
| SCHEMBL25384852 | 0.78 | MAOA (1.00) | MAOAKDM4EHSD17B10SMN1; SMN2DRD2 | |
| SCHEMBL8032032 | 0.78 | MAOA (0.64) | MAOAKDM4EALDH1A1HSD17B10GLA | |
| SCHEMBL8032028 | 0.78 | MAOA (0.64) | MAOAKDM4EALDH1A1HSD17B10GLA | |
| SCHEMBL10029583 | 0.78 | MAOA (1.00) | MAOAKDM4EHSD17B10SMN1; SMN2DRD2 | |
| SCHEMBL8278403 | 0.78 | MAOA (1.00) | MAOAKDM4EHSD17B10SMN1; SMN2DRD2 | |
| SCHEMBL20201456 | 0.77 | MAOA (0.53) | MAOAKDM4EALDH1A1HSD17B10KCNN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |