SCHEMBL803074

SCHEMBL803074

CCc1ccc(-c2ncc(CC)cn2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 4/20 0.50
METAP2 P50579 1/20 0.50
RAB9A P51151 7/20 0.47
SMN1; SMN2 Q16637 6/20 0.47
NPC1 O15118 6/20 0.47
ALDH1A1 P00352 4/20 0.47
KDM4E B2RXH2 4/20 0.47
KMT2A Q03164 4/20 0.47
MAPT P10636 3/20 0.47
HSD17B10 Q99714 3/20 0.47
MEN1 O00255 3/20 0.47
HPGD P15428 2/20 0.47
USP2 O75604 1/20 0.47
GAA P10253 1/20 0.47
RARB P10826 1/20 0.44
LMNA P02545 1/20 0.43
ADRB2 P07550 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.40
NISCH Q9Y2I1 1/20 0.40
EGFR P00533 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8526877 0.98 TP53 (0.48) TP53METAP2RAB9ASMN1; SMN2NPC1
SCHEMBL12970138 0.88 RAB9A (0.46) TP53METAP2RAB9ASMN1; SMN2NPC1
SCHEMBL7910433 0.88 SMN1; SMN2 (0.50) TP53METAP2RAB9ASMN1; SMN2NPC1
SCHEMBL8753870 0.88 RAB9A (0.54) TP53METAP2RAB9ASMN1; SMN2NPC1
SCHEMBL9601861 0.87 TP53 (0.47) TP53METAP2RAB9ASMN1; SMN2NPC1
SCHEMBL13140613 0.87 RARB (0.41) TP53METAP2RAB9ASMN1; SMN2NPC1
SCHEMBL8050481 0.86 RARB (0.49) TP53METAP2RAB9ASMN1; SMN2NPC1
SCHEMBL14156663 0.85 RAB9A (0.61) TP53RAB9ASMN1; SMN2NPC1ALDH1A1
SCHEMBL22130135 0.85 RAB9A (0.61) TP53METAP2RAB9ASMN1; SMN2NPC1
SCHEMBL8370968 0.85 LMNA (0.42) TP53METAP2RAB9ASMN1; SMN2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 209 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12043781-B2 Liquid-crystalline medium MERCK PATENT GMBH (DE) 2024-07-23 US disclosed
US-20240067879-A1 Liquid-crystal medium MERCK PATENT GMBH (DE) 2024-02-29 US disclosed
US-11873438-B2 Liquid-crystal medium MERCK PATENT GMBH (DE) 2024-01-16 US disclosed
US-20230357637-A1 LIQUID-CRYSTAL MEDIUM MERCK PATENT GMBH (DE) 2023-11-09 US disclosed
US-11802243-B2 Liquid-crystal medium MERCK PATENT GMBH (DE) 2023-10-31 US disclosed
US-20230340328-A1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2023-10-26 US disclosed
US-11788009-B2 Liquid-crystalline medium for use in a switching element MERCK PATENT GMBH (DE) 2023-10-17 US disclosed
US-20230323209-A1 LIQUID-CRYSTAL MEDIUM MERCK PATENT GMBH (DE) 2023-10-12 US disclosed
US-11781069-B2 Liquid-crystal medium MERCK PATENT GMBH (DE) 2023-10-10 US disclosed
US-20230313043-A1 OPTICAL COMPONENT MERCK PATENT GMBH (DE) 2023-10-05 US disclosed
EP-0306917-B1 A NEMATIC LIQUID CRYSTAL COMPOSITION CHISSO CORPORATION (JP) 1992-06-17 EP disclosed
US-5102578-A Electrooptics HOFFMANN-LA ROCHE INC. (US) 1992-04-07 US disclosed
EP-0281065-B1 LIQUID CRYSTAL COMPOSITION AND DISPLAY ELEMENT CHISSO CORPORATION (JP) 1991-11-27 EP disclosed
US-5021189-A Supertwisted birefringence display CHISSO CORPORATION (JP) 1991-06-04 US disclosed
US-4917818-A STEEP VOLTAGE TRANSMITTANCE USED IN WATCHES, ELECTRONIC CALCULATORS CHISSO CORPORATION (JP) 1990-04-17 US disclosed
EP-0355552-A2 Alkoxymethyl- and alkenyloxymethyl-cyclohexanes F. HOFFMANN-LA ROCHE AG (CH) 1990-02-28 EP disclosed
US-4877549-A HIGH MULTIPLEXING DISPLAY DEVICE CHISSO CORPORATION (JP) 1989-10-31 US disclosed
EP-0316186-A2 Liquid crystal compositions Chisso Corporation (JP) 1989-05-17 EP disclosed
EP-0306917-A2 A nematic liquid crystal composition CHISSO CORPORATION (JP) 1989-03-15 EP disclosed
EP-0281065-A1 Liquid crystal composition and display element CHISSO CORPORATION (JP) 1988-09-07 EP disclosed