Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 2/20 | 0.36 |
| ▸ | NQO2 | P16083 | 2/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8030865 | 1.00 | HRH3 (0.40) | HRH3ALOX5APDRD2HTR2APPARA | |
| SCHEMBL8029280 | 0.84 | GPBAR1 (0.55) | ALOX5APALDH1A1SMN1; SMN2 | |
| SCHEMBL8029284 | 0.84 | GPBAR1 (0.55) | ALOX5APALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9345393 | 0.84 | GPBAR1 (0.54) | ALOX5APALDH1A1SMN1; SMN2 | |
| SCHEMBL8029082 | 0.81 | GPBAR1 (0.53) | ALOX5APALDH1A1SMN1; SMN2 | |
| SCHEMBL8029077 | 0.81 | GPBAR1 (0.53) | ALOX5APALDH1A1SMN1; SMN2 | |
| SCHEMBL8029113 | 0.76 | THRA (0.45) | DRD2HTR2ABRD4CREBBPSYK | |
| SCHEMBL8465850 | 0.74 | LTB4R (0.43) | ALOX5APDRD2PARP10BRD4CREBBP | |
| SCHEMBL8465852 | 0.74 | LTB4R (0.43) | ALOX5APDRD2PARP10BRD4CREBBP | |
| SCHEMBL8032675 | 0.74 | GPBAR1 (0.57) | ALOX5APALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6166031-A | Substituted tetralins, chromans and related compounds in the treatment of asthma | PFIZER INC, (US) | 2000-12-26 | — | — | US | disclosed |
| WO-1989003681-A1 | SUBSTITUTED TETRALINS, CHROMANS AND RELATED COMPOUNDS IN THE TREATMENT OF ASTHMA | PFIZER INC. (US) | 1989-05-05 | — | — | WO | disclosed |
| EP-0313296-A2 | Substituted chromans and related compounds in the treatment of asthma | PFIZER INC. (US) | 1989-04-26 | — | — | EP | disclosed |