Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 17/20 | 0.55 |
| ▸ | PSEN2 | P49810 | 17/20 | 0.55 |
| ▸ | APH1B | Q8WW43 | 17/20 | 0.55 |
| ▸ | NCSTN | Q92542 | 17/20 | 0.55 |
| ▸ | APH1A | Q96BI3 | 17/20 | 0.55 |
| ▸ | PSENEN | Q9NZ42 | 17/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044877 | 0.80 | PSEN1 (0.79) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL12913746 | 0.71 | PSEN1 (1.00) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL12914012 | 0.65 | PSEN1 (0.86) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL12914124 | 0.59 | PSEN1 (1.00) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14435697 | 0.55 | TP53 (0.48) | TSHR | |
| SCHEMBL27677106 | 0.50 | CYP17A1 (0.60) | GAATSHR | |
| SCHEMBL12513634 | 0.50 | SLC6A2 (0.54) | TSHR | |
| SCHEMBL16301327 | 0.50 | CYP17A1 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL25883264 | 0.50 | SIGMAR1 (0.39) | TSHR | |
| SCHEMBL17595700 | 0.50 | GAA (0.51) | GAATSHRP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009073777-A1 | GAMMA SECRETASE MODULATORS | SCHERING CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |