Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12513634 | 0.86 | SLC6A2 (0.54) | TP53LMNAACHESLC6A2SLC6A3 | |
| SCHEMBL12295763 | 0.84 | ACHE (0.53) | ACHESLC6A2CYP2D6CYP3A4TSHR | |
| SCHEMBL23293452 | 0.84 | SLC6A4 (0.60) | SLC6A2SLC6A3SLC6A4CYP2D6KCNH2 | |
| SCHEMBL5258110 | 0.81 | SLC6A3 (0.45) | TP53SLC6A2SLC6A3HRH3SLC6A4 | |
| SCHEMBL3471054 | 0.81 | RPS6KB1 (0.51) | TP53LMNAACHECYP2D6THRB | |
| SCHEMBL8916036 | 0.81 | CYP1A2 (0.62) | LMNASLC6A2SLC6A4OPRM1OPRD1 | |
| SCHEMBL1964502 | 0.81 | CYP1A2 (0.62) | LMNASLC6A2SLC6A4OPRM1OPRD1 | |
| SCHEMBL12437238 | 0.81 | TP53 (0.45) | TP53LMNAACHESLC6A2SLC6A3 | |
| SCHEMBL28981205 | 0.80 | TP53 (0.52) | TP53LMNAACHESLC6A2SLC6A3 | |
| SCHEMBL8922757 | 0.79 | CYP1A2 (0.66) | SLC6A2HRH3SLC6A4OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007098086-A2 | HYDROXYPIPERIDINE DERIVATIVES AND USES THEREOF | AVALON PHARMACEUTICALS (US) | 2007-08-30 | — | — | WO | disclosed |